Wang Shun-Chang, Zhou Fang, Zhou Zhen-Yu, Hu Zhuang, Chang Liang, Ma Ming-de
Department of Thyroid and Breast, Huaihe Hospital, Henan University, Kaifeng 475000, People's Republic of China.
Department of Oncology, Huaihe Hospital, Henan University, Kaifeng 475000, People's Republic of China.
Biomed Pharmacother. 2017 Jun;90:659-664. doi: 10.1016/j.biopha.2017.03.098. Epub 2017 Apr 14.
Phosphatidylethanolamine-binding protein 4 (PEBP4), a member of the PEBP family, plays a pivotal role in tumor progression. However, the roles of PEBP4 in breast cancer remain unclear. Therefore, in the present study, we investigated the effects of PEBP4 on breast cancer cell proliferation, migration and invasion, and the underlying mechanism was also explored. Our results showed that the expression of PEBP4 was significantly up-regulated in breast cancer cell lines. Knockdown of PEBP4 inhibited breast cancer cell proliferation in vitro and tumor growth in vivo. Furthermore, knockdown of PEBP4 suppressed breast cancer cell migration and invasion with prevented EMT. Mechanistically, knockdown of PEBP4 inhibited breast cancer cell proliferation and migration through the inactivation of PI3K/Akt signaling pathway. In conclusion, the present study demonstrated for the first time that knockdown of PEBP4 inhibited the proliferation, invasion and tumorigenesis in breast cancer cells. Thus, PEBP4 may serve as a potential therapeutic target for the treatment of breast cancer.
磷脂酰乙醇胺结合蛋白4（PEBP4）是PEBP家族的成员之一，在肿瘤进展中起关键作用。然而，PEBP4在乳腺癌中的作用仍不清楚。因此，在本研究中，我们研究了PEBP4对乳腺癌细胞增殖、迁移和侵袭的影响，并探讨了其潜在机制。我们的结果表明，PEBP4在乳腺癌细胞系中的表达显著上调。敲低PEBP4可抑制体外乳腺癌细胞增殖和体内肿瘤生长。此外，敲低PEBP4可抑制乳腺癌细胞迁移和侵袭，并阻止上皮-间质转化（EMT）。机制上，敲低PEBP4通过使PI3K/Akt信号通路失活来抑制乳腺癌细胞增殖和迁移。总之，本研究首次证明敲低PEBP4可抑制乳腺癌细胞的增殖、侵袭和肿瘤发生。因此，PEBP4可能作为治疗乳腺癌的潜在治疗靶点。
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