Wu Zijian, Liu Bin, Zheng Xuemin, Hou Huijing, Li Ying
Tianjin Key Laboratory of Food Biotechnology, College of Biotechnology and Food Science, Tianjin University of Commerce, Tianjin, China.
Tianjin Institute of Pharmaceutical Research, Tianjin, China.
Oncotarget. 2017 Mar 14;8(11):18177-18184. doi: 10.18632/oncotarget.15255.
Phosphatidylethanolamine-binding protein 4 (PEBP4) has previously been reported to be upregulated in various cancers. However, the physiological functions of PEBP4 in gastric cancer are still unknown. Aiming to clarify the properties and role of PEBP4 in the development and invasion of gastric cancer, we performed several biological assays and a knockdown assay. The expression level of PEBP4 was shown to be significantly upregulated in gastric cancer tissue samples, and knockdown of the expression of PEBP4 induced significant inhibitory effects on cell proliferation, migration and invasiveness. In addition, it was demonstrated that PEBP4 was associated with the development and invasion of gastric cancer cells through activation of the PI3K/Akt signaling pathway. Our findings supported the hypothesis that PEBP4 might be a novel potential drug target for the treatment of gastric cancer.
磷脂酰乙醇胺结合蛋白4（PEBP4）此前已有报道称在多种癌症中上调。然而，PEBP4在胃癌中的生理功能仍不清楚。为了阐明PEBP4在胃癌发生和侵袭中的特性及作用，我们进行了多项生物学检测和一项敲低实验。结果显示，PEBP4在胃癌组织样本中的表达水平显著上调，敲低PEBP4的表达对细胞增殖、迁移和侵袭产生了显著的抑制作用。此外，研究表明PEBP4通过激活PI3K/Akt信号通路与胃癌细胞的发生和侵袭相关。我们的研究结果支持了这样一种假说，即PEBP4可能是治疗胃癌的一种新型潜在药物靶点。
