[Seasonal and circadian rhythms of the excretion of androgens and their fractions in peptic ulcer patients in the remission phase in the markedly continental climate of Transbaikalia].

Seasonal rhythms of androgen excretion were studied in 247 normal subjects and 213 patients with peptic ulcer in the stage of remission. Circadian rhythms were examined in 84 patients and excretion of androgen fractions in 81 patients. The patients manifested changes in the seasonal rhythms of androgen excretion. In winter period, androgen excretion was higher in the patients with peptic ulcer but in spring, the normal subjects had a higher excretion than patients, whereas in summer the patients had a higher excretion than normal subjects. Despite the preservation of the rhythmical pattern the patients demonstrated changes in the rhythm expressed in the decreased amplitude of seasonal fluctuations and deformation of the seasonal rhythm. Circadian rhythms differed only at some seasons. The difference in excretion of androgens (dehydroandrosterone and androsterone) were revealed at individual seasons. Deformation of the rhythms in peptic ulcer patients can be corrected by application of early preventive measures aimed at normalization of the excretory rhythm and restoration of the rhythm characteristic of the regional climatic zone under consideration.