Department of Microbiology and Immunology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, United States.
Front Cell Infect Microbiol. 2019 Sep 11;9:318. doi: 10.3389/fcimb.2019.00318. eCollection 2019.
As free living organisms, fungi are challenged with a variety of environmental insults that threaten their cellular processes. In some cases, these challenges mimic conditions present within mammals, resulting in the accidental selection of virulence factors over evolutionary time. Be it within a host or the soil, fungi must contend with environmental challenges through the production of stress effector proteins while maintaining factors required for viability in any condition. Initiation and upkeep of this balancing act is mainly under the control of kinases that affect the propensity and selectivity of protein translation. This review will focus on kinases in pathogenic fungi that facilitate a virulence phenotype through translational control.
作为自由生活的生物体，真菌面临着各种环境威胁，这些威胁会影响它们的细胞过程。在某些情况下，这些挑战类似于哺乳动物体内的情况，导致在进化过程中意外选择了毒力因子。无论是在宿主内还是在土壤中，真菌都必须通过产生应激效应蛋白来应对环境挑战，同时保持在任何条件下生存所需的因素。这种平衡行为的启动和维持主要受激酶的控制，激酶会影响蛋白质翻译的倾向和选择性。本综述将重点介绍致病性真菌中的激酶，这些激酶通过翻译控制促进毒力表型。
