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最接近的脊椎动物姐妹群中卵母细胞成熟和排卵的调控。

The regulation of oocyte maturation and ovulation in the closest sister group of vertebrates.

机构信息

Bioorganic Research Institute, Suntory Foundation for Life Sciences, Kyoto, Japan.

Research Fellow of Japan Society for the Promotion of Science, Tokyo, Japan.

出版信息

Elife. 2019 Oct 1;8:e49062. doi: 10.7554/eLife.49062.

DOI:10.7554/eLife.49062
PMID:31573508
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6786877/
Abstract

Ascidians are the closest living relatives of vertebrates, and their study is important for understanding the evolutionary processes of oocyte maturation and ovulation. In this study, we first examined the ovulation of Type A by monitoring follicle rupture in vitro, identifying a novel mechanism of neuropeptidergic regulation of oocyte maturation and ovulation. vasopressin family peptide (CiVP) directly upregulated the phosphorylation of extracellular signal-regulated kinase (CiErk1/2) via its receptor. CiVP ultimately activated a maturation-promoting factor, leading to oocyte maturation via germinal vesicle breakdown. CiErk1/2 also induced expression of matrix metalloproteinase (CiMMP2/9/13) in the oocyte, resulting in collagen degradation in the outer follicular cell layer and liberation of fertile oocytes from the ovary. This is the first demonstration of essential pathways regulating oocyte maturation and ovulation in ascidians and will facilitate investigations of the evolutionary process of peptidergic regulation of oocyte maturation and ovulation throughout the phylum Chordata.

摘要

海鞘是脊椎动物最接近的现存亲属，它们的研究对于理解卵母细胞成熟和排卵的进化过程很重要。在这项研究中，我们首先通过体外监测滤泡破裂来检查 A 型排卵，确定了一种新的神经肽调节卵母细胞成熟和排卵的机制。血管加压素家族肽（CiVP）通过其受体直接上调细胞外信号调节激酶（CiErk1/2）的磷酸化。CiVP 最终激活成熟促进因子，导致卵母细胞通过卵母细胞核破裂成熟。CiErk1/2 还诱导卵母细胞中基质金属蛋白酶（CiMMP2/9/13）的表达，导致外层滤泡细胞层中的胶原降解，并使可育卵母细胞从卵巢中释放出来。这首次证明了在海鞘中调节卵母细胞成熟和排卵的必要途径，并将促进对整个脊索动物门中肽调节卵母细胞成熟和排卵的进化过程的研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ed2/6786877/3cb53be8fcbf/elife-49062-fig7-figsupp1.jpg
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2
In situ localization of vasotocin receptor gene transcripts in the brain-pituitary-gonadal axis of the catfish Heteropneustes fossilis: a morpho-functional study.鲶鱼（Heteropneustes fossilis）脑-垂体-性腺轴中血管加压素受体基因转录本的原位定位：一项形态功能研究
Fish Physiol Biochem. 2019 Jun;45(3):885-905. doi: 10.1007/s10695-018-0590-1. Epub 2018 Dec 3.
3
Follicle rupture during ovulation with an emphasis on recent progress in fish models.
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Front Endocrinol (Lausanne). 2023 Sep 29;14:1260600. doi: 10.3389/fendo.2023.1260600. eCollection 2023.
4
A Putative Role of Vasopressin/Oxytocin-Type Neuropeptide in Osmoregulation and Feeding Inhibition of .加压素/催产素型神经肽在渗透压调节和进食抑制中的假定作用 。 （原文句子不完整，这里按字面翻译）
Int J Mol Sci. 2023 Sep 20;24(18):14358. doi: 10.3390/ijms241814358.
5
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Front Endocrinol (Lausanne). 2023 Aug 21;14:1151299. doi: 10.3389/fendo.2023.1151299. eCollection 2023.
6
Relaxin-like Gonad-Stimulating Peptides in Asteroidea.海星纲中的类松弛素性腺刺激肽。
Biomolecules. 2023 Apr 30;13(5):781. doi: 10.3390/biom13050781.
7
Changes in Ovulation-Related Gene Expression during Induced Ovulation in the Amur Sturgeon () Ovarian Follicles.诱导排卵过程中史氏鲟（）卵巢滤泡中与排卵相关基因表达的变化。
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4
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5
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6
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7
Identification of jellyfish neuropeptides that act directly as oocyte maturation-inducing hormones.直接作为卵母细胞成熟诱导激素的水母神经肽的鉴定。
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8
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Front Endocrinol (Lausanne). 2017 Nov 2;8:299. doi: 10.3389/fendo.2017.00299. eCollection 2017.
9
Heterodimerization of the prostaglandin E2 receptor EP2 and the calcitonin receptor CTR.前列腺素E2受体EP2与降钙素受体CTR的异源二聚化。
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10
The epidermal growth factor network: role in oocyte growth, maturation and developmental competence.表皮生长因子网络：在卵母细胞生长、成熟和发育能力中的作用。
Hum Reprod Update. 2018 Jan 1;24(1):1-14. doi: 10.1093/humupd/dmx029.