Diagnostic Imaging, Hospital for Sick Children, Toronto, Canada; Neurosciences and Mental Health Program, Research Institute, Hospital for Sick Children, Toronto, Canada.
Diagnostic Imaging, Hospital for Sick Children, Toronto, Canada; Neurosciences and Mental Health Program, Research Institute, Hospital for Sick Children, Toronto, Canada; Department of Psychology, University of Toronto, Toronto, Canada.
Biol Psychol. 2020 Jan;149:107774. doi: 10.1016/j.biopsycho.2019.107774. Epub 2019 Sep 28.
Impairments in social functioning are characteristic of autism spectrum disorder (ASD). Differences in functional networks during face processing in ASD compared to controls have been reported; however, the spatial-temporal dynamics of networks underlying affective processing are still not well understood. The current magnetoencephalography study examined whole-brain functional connectivity to implicit happy and angry faces in 104 adults with and without ASD. A network of reduced gamma band (30-55 Hz) phase synchrony occurring 80-308 ms following angry face presentation was found in adults with ASD compared to controls. The network involved widespread connections primarily anchored in frontal regions, including bilateral orbitofrontal areas, bilateral inferior frontal gyri, and left middle frontal gyrus extending to occipital, temporal, parietal, and subcortical regions. This finding suggests disrupted long-range neuronal communication to angry faces. Additionally, reduced gamma band-specific connectivity may reflect altered E/I balance in brain regions critical for emotional face processing in ASD.
社交功能障碍是自闭症谱系障碍（ASD）的特征。与对照组相比，ASD 患者在处理面部时功能性网络存在差异，但情感处理的网络时空动力学仍不清楚。本项脑磁图研究共纳入 104 名 ASD 患者和非 ASD 对照者，旨在检测他们对隐含的快乐和愤怒面孔的全脑功能连接。与对照组相比，ASD 患者在呈现愤怒面孔后 80-308ms 时出现了伽马频带（30-55Hz）相位同步性降低的网络。该网络涉及广泛的连接，主要锚定在前额区域，包括双侧眶额区、双侧额下回和左侧中额回延伸至枕叶、颞叶、顶叶和皮质下区域。这一发现表明，对愤怒面孔的长程神经元通讯受到了破坏。此外，伽马频带特异性连接的减少可能反映了 ASD 患者中对情绪面孔处理至关重要的脑区中 E/I 平衡的改变。
