MacLeod K M, McNeill J H
Can J Physiol Pharmacol. 1985 Jan;63(1):52-7. doi: 10.1139/y85-009.
The influence of experimental diabetes induced by streptozotocin on responses of rat isolated aortae and portal veins to noradrenaline, 5-hydroxytryptamine, and KCl was examined 7, 100, 180, and 360 days after the onset of diabetes. No significant changes in reactivity were seen 7 days after the onset of diabetes. After 100 days aortae from diabetic rats were supersensitive (defined as a significant increase in the pD2 value) to noradrenaline. However, 180 days after the onset of diabetes, the sensitivity of diabetic aortae to noradrenaline was not significantly different from control, while the responsiveness (defined as the maximum developed tension divided by cross-sectional area of aorta) to 5-hydroxytryptamine was reduced. A generalized increase in both the sensitivity and responsiveness of diabetic aortae to all three agonists was observed after 360 days of diabetes. In contrast, no changes in either the sensitivity or the responsiveness of portal veins to noradrenaline, 5-hydroxytryptamine, or KCl could be detected at any time after the onset of diabetes. These results indicate that changes in vascular reactivity can be detected with increasing duration of experimental diabetes. However, these changes do not follow a consistent pattern and are not seen in all parts of the vasculature.
在糖尿病发病后7天、100天、180天和360天，研究了链脲佐菌素诱导的实验性糖尿病对大鼠离体主动脉和门静脉对去甲肾上腺素、5-羟色胺和氯化钾反应的影响。糖尿病发病7天后，反应性未见明显变化。糖尿病大鼠主动脉在发病100天后对去甲肾上腺素超敏（定义为pD2值显著增加）。然而，糖尿病发病180天后，糖尿病主动脉对去甲肾上腺素的敏感性与对照组无显著差异，而对5-羟色胺的反应性（定义为最大收缩张力除以主动脉横截面积）降低。糖尿病360天后，观察到糖尿病主动脉对所有三种激动剂的敏感性和反应性普遍增加。相比之下，糖尿病发病后的任何时间，门静脉对去甲肾上腺素、5-羟色胺或氯化钾的敏感性或反应性均未检测到变化。这些结果表明，随着实验性糖尿病病程的延长，可以检测到血管反应性的变化。然而，这些变化并不遵循一致的模式，且并非在血管系统的所有部位都能看到。
