利用炎症生物标志物验证日本人群的饮食炎症指数：一项 JPHC-FFQ 验证研究的横断面研究。

Validating the dietary inflammatory index using inflammatory biomarkers in a Japanese population: A cross-sectional study of the JPHC-FFQ validation study.

机构信息

Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan.

出版信息

Nutrition. 2020 Jan;69:110569. doi: 10.1016/j.nut.2019.110569. Epub 2019 Aug 17.

DOI:10.1016/j.nut.2019.110569

PMID:31574409

Abstract

OBJECTIVES

Persistent low-grade inflammation is related to the development of many chronic diseases. The dietary inflammatory index (DII®) is designed to assess the potential effects of diet on an individual's inflammation status. The aim of this study was to evaluate the construct validity of the DII using inflammation biomarkers in Japanese adults.

METHODS

Overall, 565 participants from the food frequency questionnaire (FFQ) validation study of the Japan Public Health Center-Based Prospective Cohort were included in the present study. This cohort consisted of two independently recruited and examined, cohorts I and II. Dietary records (DR) were collected for 28 d and two FFQs were administered. Blood samples also were obtained for the analysis of high-sensitivity C-reactive protein (hs-CRP) and interleukin (IL)-6 concentrations. DII scores were calculated from DR and FFQ using energy-adjusted dietary intakes by the density method. Higher DII scores indicate a greater proinflammatory potential of the diet. The associations between DII and inflammatory biomarkers were assessed using regression models adjusted for age, body mass index, smoking status, and amount of physical activity.

RESULTS

The associations between DR- and FFQ-derived DII scores were moderate. Higher DR-derived DII scores, representing a more proinflammatory diet, were significantly correlated with IL-6, but not hs-CRP, concentrations in men. The geometric means of IL-6 concentrations in the lowest and highest DII quartiles were 1.05 and 1.33 pg/mL (P = 0.02 for trend) in cohort I, and 1.00 and 1.24 pg/mL (P = 0.03 for trend) in cohort II, respectively. Furthermore, IL-6 concentration appeared to increase across DII quartiles calculated from FFQ in men. However, there was no association between DII and inflammatory biomarkers in women.

CONCLUSIONS

Null findings in women may reflect the generally lower levels of chronic systemic inflammation among Japanese versus their Western counterparts. These findings indicate that DII may be applied to measure the potential effects of diet on chronic diseases through inflammatory pathways in Japanese men.

摘要

目的

持续性低度炎症与许多慢性疾病的发展有关。饮食炎症指数（DII®）旨在评估饮食对个体炎症状态的潜在影响。本研究旨在使用日本成年人的炎症生物标志物评估 DII 的结构效度。

方法

本研究共纳入了来自日本公共卫生中心前瞻性队列研究的食物频率问卷（FFQ）验证研究的 565 名参与者。该队列由两个独立招募和检查的队列 I 和队列 II 组成。收集了 28 天的饮食记录（DR）和两份 FFQ。还采集了血液样本，用于分析高敏 C 反应蛋白（hs-CRP）和白细胞介素（IL）-6 浓度。DR 和 FFQ 的 DII 评分通过密度法的能量调整膳食摄入量进行计算。较高的 DII 评分表示饮食的促炎潜力更大。使用回归模型调整年龄、体重指数、吸烟状况和体力活动量后，评估 DII 与炎症生物标志物之间的关联。

结果

DR 和 FFQ 衍生的 DII 评分之间的相关性中等。代表更促炎饮食的更高 DR 衍生 DII 评分与男性的 IL-6 浓度显著相关，但与 hs-CRP 浓度无关。队列 I 中，最低和最高 DII 四分位数的 IL-6 浓度的几何平均值分别为 1.05 和 1.33 pg/mL（趋势 P=0.02），队列 II 中分别为 1.00 和 1.24 pg/mL（趋势 P=0.03）。此外，男性 FFQ 计算的 DII 四分位数中 IL-6 浓度似乎呈递增趋势。然而，在女性中，DII 与炎症生物标志物之间没有关联。