He Huabin, Xiao Xifeng, Yang Junjun, Lei Meixian
Department of Cardiovascular Medicine, Jiu jiang No. 1 People's Hospital, Jiujiang, 332000, China.
Department of Gastroenterology, Jiu jiang No. 1 People's Hospital, Jiujiang, 332000, China.
Sci Rep. 2024 Dec 4;14(1):30235. doi: 10.1038/s41598-024-78307-4.
Studies on the association between dietary inflammatory index (DII) and chronic kidney disease (CKD) are limited. We aimed to examine the association between DII and CKD among U.S. adults with particular attention paid to sex differences. A total of 19317participants were included in this study. The exposure variable was DII, which was calculated based on overall inflammatory effect scores. The outcome was CKD, defined as estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m or urinary albumin/creatinine (uACR) ≥ 30 mg/g. The mean (SD) of age our study participants was 47.84 (18.35); and the mean (SD) of DII was 1.50 (1.91) (median 1.74). In multivariate logistic regression analysis, we observed that the OR value (95%CI) of CKD is 1.19 (1.14, 1.23), 1.12 (1.06, 1.19), and 1.16 (1.06, 1.27) in models 1, 2 and 3 for Per SD increment of DII. Compared with Participants with Q1(DII < 0.15), the adjusted ORs for participants in Q2 (0.15 ≤ DII < 1.74), Q3 (1.74 ≤ DII < 3.02) and Q4 (≥ 3.02)were 1.46 (95% CI 1.14-1.88), 1.55 (95% CI 1.20-1.99) and 1.52 (95% CI 1.17, 1.98) ( p for trend < 0.05), respectively. However, this study observed that the independent positive correlation between DII and CKD appeared in women rather than men. Higher DII levels were significantly and linearly associated with an increased prevalence of chronic kidney disease, and sex modified the association. This suggests that gender-specific dietary interventions can be developed to reduce the risk of CKD.
关于饮食炎症指数（DII）与慢性肾脏病（CKD）之间关联的研究有限。我们旨在研究美国成年人中DII与CKD之间的关联，并特别关注性别差异。本研究共纳入19317名参与者。暴露变量为DII，其基于总体炎症效应得分计算得出。结局为CKD，定义为估算肾小球滤过率（eGFR）<60 mL/min/1.73 m²或尿白蛋白/肌酐（uACR）≥30 mg/g。我们研究参与者的年龄均值（标准差）为47.84（18.35）；DII的均值（标准差）为1.50（1.91）（中位数为1.74）。在多因素逻辑回归分析中，我们观察到，在模型1、2和3中，DII每增加1个标准差，CKD的OR值（95%CI）分别为1.19（1.14，1.23）、1.12（1.06，1.19）和1.16（1.06，1.27）。与处于第一四分位数（DII<0.15）的参与者相比，处于第二四分位数（0.15≤DII<1.74）、第三四分位数（1.74≤DII<3.02）和第四四分位数（≥3.02）的参与者的校正OR值分别为1.46（95%CI 1.14 - 1.88）、1.55（95%CI 1.20 - 1.99）和1.52（95%CI 1.17，1.98）（趋势p<0.05）。然而，本研究观察到DII与CKD之间的独立正相关出现在女性而非男性中。较高的DII水平与慢性肾脏病患病率的增加显著且呈线性相关，并且性别改变了这种关联。这表明可以制定针对性别的饮食干预措施以降低CKD风险。
