Department of Medical Science, Graduate School of Ajou University, Suwon, Republic of Korea.
Department of Health Administration, College of Health Science, Dankook University, Cheonan, Republic of Korea.
Arch Gerontol Geriatr. 2020 Jan-Feb;86:103937. doi: 10.1016/j.archger.2019.103937. Epub 2019 Sep 11.
Aging causes both structural and functional changes in the skeletal muscle, and is associated with changes in body composition form, which results in an increased incidence of cardiovascular death. Handgrip strength (HGS) is a simple, fast, reliable, and cost-effective tool for measuring muscle strength.
We aimed to investigate which index was most suitable for predicting cardiovascular disease (CVD), and suggested the optimal cut-off points based on the handgrip strength index. In addition, we aimed to identify the effects of weak HGS, as determined by applying the optimal cut point on the occurrence of CVD.
A total of 8494 older men and women aged over 45 years from the Korean Longitudinal Study of Aging (KLoSA) were included in this study at baseline. We performed general estimating equations (GEE) with independent correlation structure to assess whether handgrip strength is longitudinally related to occurrence of CVDs such as heart disease or stroke reported from 1 st to 6th wave of KLoSA.
The relative HGS was strongly associated with CVD in both sexes, and the best fit model was in that in comparison to dominant HGS and absolute HGS. In addition, we calculated the optimal cut point for CVD based on the relative HGS in this study (men: 2.52 and women: 1.55, respectively), and demonstrated that low HGS, as determined by applying relative HGS cut points, was associated with a higher OR for CVD compared to normal HGS; the associations observed were consistent between the sexes.
Our findings suggest that HGS has the potential to be a valuable screening tool for cardiovascular risk in clinical settings; this is advantageous in situations where blood sampling is not possible since HGS is easily measured and highly reproducible. It is necessary to pay attention to weak grip strength against body size in the elderly population.
衰老会导致骨骼肌的结构和功能发生变化，并与身体成分形态的变化相关，这会导致心血管死亡的发生率增加。握力（HGS）是一种简单、快速、可靠且具有成本效益的肌肉力量测量工具。
我们旨在研究哪个指标最适合预测心血管疾病（CVD），并根据握力强度指数建议最佳截断点。此外，我们旨在确定应用最佳截断点确定的弱 HGS 对 CVD 发生的影响。
本研究共纳入 8494 名年龄在 45 岁以上的来自韩国老龄化纵向研究（KLoSA）的男女参与者。我们使用具有独立相关结构的一般估计方程（GEE）来评估握力是否与从 KLoSA 的第 1 波到第 6 波报告的 CVD 等心脏病或中风等疾病的发生具有纵向相关性。
相对 HGS 在两性中均与 CVD 密切相关，最佳拟合模型为与优势 HGS 和绝对 HGS 相比。此外，我们根据本研究中的相对 HGS 计算了 CVD 的最佳截断点（男性：2.52，女性：1.55），并表明与正常 HGS 相比，应用相对 HGS 截断点确定的低 HGS 与 CVD 的更高 OR 相关；两性之间观察到的关联是一致的。
我们的研究结果表明，HGS 有可能成为临床环境中心血管风险的有价值的筛查工具；由于 HGS 易于测量且高度可重复，因此在无法采血的情况下具有优势。在老年人群中，需要注意针对身体大小的弱握力。
