Steinhauser Motta João Pedro, Lapa E Silva José Roberto, Samary Lobato Caroliny, Mendonça Vanessa Souza, Steffen Ricardo E
Universidade Federal do Rio de Janeiro, Instituto de Doenças do Tórax.
Universidade Federal do Rio de Janeiro.
Medicine (Baltimore). 2019 Sep;98(39):e17242. doi: 10.1097/MD.0000000000017242.
Lung cancer is a major health problem, with estimates of 1.6 million tumor-related deaths annually worldwide. The emergence of endobronchial ultrasound (EBUS), a minimally invasive procedure capable of providing valuable information for primary tumor diagnosis and mediastinal staging, significantly changed the approach of pulmonary cancer, becoming part of the routine mediastinal evaluation of lung cancer in developed countries. Some economic evaluation studies published in the last 10 years have already analyzed the incorporation of the EBUS technique in different health systems. The aim of this systematic review is to synthesize the relevant information brought by these studies to better understand the economic effect of the implementation of this staging tool.
The systematic review will be reported using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement guidelines. Eletronic databases (Medline, Lilacs, Embase, Cochrane Library of Trials, Web of Science, Scopus, National Health System Economic Evaluation Database) will be searched for full economic analyses regarding the use of EBUS-guided transbronchial needle aspiration (EBUS-TBNA) compared to the surgical technique of mediastinoscopy for the mediastinal staging of lung cancer. Two authors will perform the selection of studies, data extraction, and the assessment of risk of bias. Occasionally, a senior reviewer will participate, if necessary, on study selection or data extraction.
Results will be published in a peer-reviewed journal.
This review may influence a more cost-effective mediastinal staging approach for patients with lung cancer around the world and help health decision makers decide whether the EBUS-TBNA technique should be incorporated into their health systems and how to do it efficiently.
PROSPERO 42019107901.
肺癌是一个重大的健康问题，据估计全球每年有160万例与肿瘤相关的死亡病例。支气管内超声（EBUS）的出现是一种微创检查方法，能够为原发性肿瘤诊断和纵隔分期提供有价值的信息，显著改变了肺癌的诊疗方式，在发达国家已成为肺癌常规纵隔评估的一部分。过去10年发表的一些经济评估研究已经分析了EBUS技术在不同卫生系统中的应用情况。本系统评价的目的是综合这些研究提供的相关信息，以更好地了解这种分期工具实施的经济效果。
本系统评价将按照系统评价和Meta分析的首选报告项目（PRISMA）声明指南进行报告。将检索电子数据库（Medline、Lilacs、Embase、Cochrane试验图书馆、科学网、Scopus、国家卫生系统经济评估数据库），以获取关于使用EBUS引导的经支气管针吸活检（EBUS-TBNA）与纵隔镜手术技术用于肺癌纵隔分期的全面经济分析。两名作者将进行研究选择、数据提取和偏倚风险评估。如有必要，一名资深审稿人将参与研究选择或数据提取。
研究结果将发表在同行评审期刊上。
本综述可能会影响全球肺癌患者更具成本效益的纵隔分期方法，并帮助卫生决策者决定是否应将EBUS-TBNA技术纳入其卫生系统以及如何高效实施。
PROSPERO 42019107901。
