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2'-脱氧鸟苷对人淋巴细胞反应的影响。II. 2'-脱氧鸟苷增强PWM诱导的B细胞分化。

The effect of 2'deoxyguanosine on human lymphocyte responses. II. 2'deoxyguanosine enhances PWM-induced B cell differentiation.

作者信息

Hanglow A C, Lydyard P M

出版信息

Clin Exp Immunol. 1985 Mar;59(3):659-65.

PMID:3157516
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1576932/
Abstract

Addition of 40 microM 2'deoxyguanosine (2'd Guo) results in enhancement of human lymphocyte cultures stimulated with pokeweed mitogen, assessed by staining intracytoplasmic immunoglobulins. Furthermore, B cell responses were enhanced under experimental conditions favouring T cell suppression rather than help. Experiments with enriched B cell fractions indicate that 2'dGuo does not directly stimulate B cell responses. The enhancement by 2'dGuo was still observed in the presence of irradiated (non-proliferating) T cells. The mechanism of enhancement by 2'dGuo is discussed in terms of its effect on proliferation-independent suppressor T cells.

摘要

添加40微摩尔的2'-脱氧鸟苷（2'd Guo）可增强经商陆有丝分裂原刺激的人淋巴细胞培养物，这是通过对细胞质内免疫球蛋白进行染色来评估的。此外，在有利于T细胞抑制而非辅助的实验条件下，B细胞反应得到增强。对富集的B细胞组分进行的实验表明，2'dGuo不会直接刺激B细胞反应。在存在经辐照（不增殖）的T细胞的情况下，仍可观察到2'dGuo的增强作用。根据其对不依赖增殖的抑制性T细胞的作用，讨论了2'dGuo的增强机制。

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Differential sensitivity to 2'-deoxyguanosine of antigen-specific and nonspecific suppressor T cells in delayed hypersensitivity.迟发型超敏反应中抗原特异性和非特异性抑制性T细胞对2'-脱氧鸟苷的差异敏感性
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The effect of 2'deoxyguanosine on human lymphocyte responses. I. 2'deoxyguanosine enhances T lymphocyte responses.2'-脱氧鸟苷对人淋巴细胞反应的影响。I. 2'-脱氧鸟苷增强T淋巴细胞反应。
Clin Exp Immunol. 1985 Mar;59(3):653-8.

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