自发性和刀豆蛋白A诱导的抑制性淋巴细胞：一项比较研究。
Spontaneous and conA-induced suppressor lymphocytes: a comparative study.
作者信息
Gattringer C, Huber H, Michlmayr G, Braunsteiner H
出版信息
Immunobiology. 1981;159(3):293-306. doi: 10.1016/S0171-2985(81)80087-3.
Suppressor monocytes, Concanavalin A(ConA)-induced suppressor T cells, and short-lived suppressor lymphocytes have been describe in humans. The present study was performed to evaluate spontaneous suppression in a test system similar to that employed for the demonstration of ConA-induced suppressor cells: Lymphocytes were either stimulated by ConA (= induced suppressor cells) or immediately mitomycin-treated (= spontaneous suppressor cells). Both preparations were tested for their capacity to suppress mitogen-induced proliferation of autologous cells. Depletion of monocytes or B lymphocytes did not affect spontaneous suppression. The active cells were short-lived in vitro. Therefore the net increase in suppressor activity generated by preculture with ConA is in part related to a loss of spontaneous inhibitory activity in the control cultures kept without mitogen. Spontaneous suppressor cell activity was comparable to that of ConA-induced suppressor cells.
在人类中已描述了抑制性单核细胞、刀豆蛋白A（ConA）诱导的抑制性T细胞和短命抑制性淋巴细胞。本研究旨在评估在一个类似于用于证明ConA诱导的抑制性细胞的测试系统中的自发抑制作用：淋巴细胞要么用ConA刺激（=诱导抑制性细胞），要么立即用丝裂霉素处理（=自发抑制性细胞）。对这两种制剂抑制有丝分裂原诱导的自体细胞增殖的能力进行了测试。单核细胞或B淋巴细胞的耗竭不影响自发抑制作用。活性细胞在体外寿命较短。因此，用ConA预培养产生的抑制活性的净增加部分与在没有有丝分裂原的对照培养物中自发抑制活性的丧失有关。自发抑制性细胞活性与ConA诱导的抑制性细胞活性相当。
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