白色念珠菌对无菌小鼠消化道定殖的个体演化
Individual evolution of digestive tract colonization of holoxenic mice by Candida albicans.
作者信息
Walbaum S, Dujardin L
出版信息
Infect Immun. 1985 May;48(2):433-8. doi: 10.1128/iai.48.2.433-438.1985.
Abstract
Oral administration of various concentrations of Candida albicans to 6-day-old mice established colonization of the digestive tract without mortality. After being weaned (day 21), the development of colonization was studied in a group of mice by daily counting of the number of CFU contained in the feces of each animal. Two features concerning the development of colonization were noted. The course of colonization in individual mice was highly erratic and lead to either transitory or sometimes long-lasting colonization. These results show the importance of a dynamic study of colonization, a condition necessary for any experimental study.
摘要
给6日龄小鼠口服不同浓度的白色念珠菌，可在不导致死亡的情况下在消化道建立定植。断奶后（第21天），通过每天计数每组小鼠粪便中的菌落形成单位（CFU）数量，研究了一组小鼠定植的发展情况。关于定植发展情况有两个特征值得注意。个体小鼠的定植过程极不稳定，会导致短暂或有时长期的定植。这些结果表明了动态研究定植的重要性，这是任何实验研究的必要条件。
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