Samonis G, Dassiou M, Anastassiadou H
Department of Medical Oncology, University of Crete, Heraklion, Greece.
J Chemother. 1994 Feb;6(1):50-2. doi: 10.1080/1120009x.1994.11741129.
A group of three-month old, male Crl:CD1(ICR) BR mice, was fed chow containing Candida albicans, while another group of the same type of mice was fed regular chow. Both groups were treated subsequently with either antibiotics or normal saline for 10 days. Stool cultures were performed before treatment, at the end of treatment, and one week after the end of treatment, to determine the level of colonization of the gastrointestinal tract by the yeast. The stools of mice fed Candida and treated with antibiotics had substantially higher Candida counts than control mice fed C. albicans and treated with saline. The highest concentrations of the yeast were observed in the stools of mice treated with cefotaxime as compared to those of mice treated with pefloxacin, amikacin and amoxicillin. No Candida was found in the stools of mice fed regular chow and treated with antibiotics or saline. Dissemination of Candida was not observed in the visceral organs of any mouse.
一组三个月大的雄性Crl:CD1(ICR)BR小鼠被喂食含有白色念珠菌的食物，而另一组同类型小鼠则喂食普通食物。随后两组小鼠均用抗生素或生理盐水处理10天。在治疗前、治疗结束时以及治疗结束后一周进行粪便培养，以确定胃肠道中酵母菌的定植水平。喂食白色念珠菌并接受抗生素治疗的小鼠粪便中的念珠菌计数明显高于喂食白色念珠菌并接受生理盐水治疗的对照小鼠。与接受培氟沙星、阿米卡星和阿莫西林治疗的小鼠相比，在接受头孢噻肟治疗的小鼠粪便中观察到酵母菌的最高浓度。喂食普通食物并接受抗生素或生理盐水治疗的小鼠粪便中未发现念珠菌。在任何小鼠的内脏器官中均未观察到念珠菌的播散。
