钯催化的 O-甲基酮肟与氨基二羧酸的脱羧邻位酰胺化反应。
Palladium-catalyzed decarboxylative ortho-amidation of O-methyl ketoximes with oxamic acids.
机构信息
CAS Key Laboratory of Soft Matter Chemistry, Hefei National Laboratory for Physical Sciences at Microscale and Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, P. R. China.
出版信息
Chem Commun (Camb). 2019 Oct 15;55(83):12551-12554. doi: 10.1039/c9cc06460e.
The first palladium-catalyzed ortho-amidation of ketoximes has been developed with readily available, easy to handle and environment-friendly N,N-disubstituted oxamic acids as the amidation sources. When N-monosubstituted oxamic acids are used as the substrates, the formed ortho-amidated ketoximes undergo further intramolecular cyclization to provide 3-methyleneisoindolinones.
发展了首例钯催化的酮肟邻位酰胺化反应，使用易得、易处理且环境友好的 N,N-二取代羟胺酸作为酰胺化试剂。当使用 N-单取代羟胺酸作为底物时，生成的邻位酰胺化酮肟进一步进行分子内环化，得到 3-亚甲基异吲哚啉酮。
Zotero 插件