钯催化的可见光条件下 4CzIPN 介导的 O-甲基酮肟与α-酮酸的脱羧酰化反应。
A Palladium-Catalyzed 4CzIPN-Mediated Decarboxylative Acylation Reaction of O-Methyl Ketoximes with α-Keto Acids under Visible Light.
机构信息
Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science Soochow University, Suzhou 215123, China.
School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang 453000, China.
出版信息
Molecules. 2022 Mar 18;27(6):1980. doi: 10.3390/molecules27061980.
This work presents a palladium-catalyzed oxime ether-directed ortho-selective benzoylation using benzoylformic acid as the acyl source with a palladium catalyst and 4CzIPN as the co-catalyst under light. Various non-symmetric benzophenone derivatives were obtained in moderate to good yields. A preliminary mechanism study revealed that the reaction proceeds through a free radical pathway.
本文提出了一种钯催化的肟醚导向的邻位选择性苯甲酰化反应，使用苯甲酰甲酸作为酰基源，钯催化剂和 4CzIPN 作为共催化剂，并在光照下进行。各种非对称二苯甲酮衍生物都以中等至良好的产率得到。初步的机理研究表明，反应是通过自由基途径进行的。
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