Faisal Raghad, Alhalabi Marwan, Alquobaili Faizeh
Clinical Biochemistry and Microbiology Department, Faculty of Pharmacy, Damascus University, Syria.
Embryology and Genetics, Faculty of Medicine, Damascus University, Syria.
Ann Med Surg (Lond). 2022 Jul 12;80:104126. doi: 10.1016/j.amsu.2022.104126. eCollection 2022 Aug.
Vitamin D has recently raised a great deal of controversy, not because of its traditional role of absorbing calcium and maintaining bone health, but because of its unconventional role as an endocrine factor and the extent of its impact when linked to its specific receptors (VDR) found in different tissues. Research has raced trying to find its different roles in those tissues and its association with different clinical or medical conditions, and among these cases, its role in reproductive functions and fertility in women, these studies conflicted between supporting and denying the role of vitamin D in reproductive function and rejecting this hypothesis according to the results of their study.
The in vitro fertilization process allowed us to study the possible hypotheses, as this technique provides an opportunity to study the relationship between vitamin D levels with the in vitro fertilization outcomes, thus providing us with an idea of the relationship of vitamin D with fertility in women. In order to study this relationship, we designed our research as a cross-sectional study to confirm or deny this claim. Vitamin D was measured in the blood and in the follicular fluid for all cases using the electrochemiluminescence immunoassay (ECLIA) for the assay of total vitamin D, then IVF outcomes were compared with the levels of vitamin D in the blood.
the levels of vitamin D are not related to the criteria of eggs such as the number of eggs and the maturity rate (MR) of eggs, but they are correlated in a statistically significant manner with the fertility rate (FR), and at the same time the levels of vitamin D in the blood were completely independent of the clinical pregnancy rate (CPR).
blood vitamin D levels will affect the FR when its levels in the blood drop below a specified value, vitamin D did not correlate with the CPR. In the long run, there is scope for more research projects on vitamin D. Future research could include case-control studies of patients on vitamin D supplementation, and the study of its correlation with IVF outcomes.
维生素D最近引发了诸多争议，并非因其吸收钙和维持骨骼健康的传统作用，而是因其作为一种内分泌因子的非传统作用，以及与在不同组织中发现的特定受体（VDR）相关联时所产生影响的程度。研究竞相探寻其在这些组织中的不同作用及其与不同临床或医学状况的关联，在这些研究中，其在女性生殖功能和生育能力方面的作用，这些研究在支持和否定维生素D在生殖功能中的作用以及根据研究结果拒绝这一假设之间存在冲突。
体外受精过程使我们能够研究可能的假设，因为这项技术为研究维生素D水平与体外受精结果之间的关系提供了机会，从而让我们了解维生素D与女性生育能力之间的关系。为了研究这种关系，我们将研究设计为横断面研究以证实或否定这一说法。使用电化学发光免疫分析法（ECLIA）测定所有病例血液和卵泡液中的总维生素D，然后将体外受精结果与血液中的维生素D水平进行比较。
维生素D水平与卵子的标准如卵子数量和卵子成熟率（MR）无关，但与生育率（FR）具有统计学上的显著相关性，同时血液中的维生素D水平与临床妊娠率（CPR）完全无关。
当血液中维生素D水平降至特定值以下时会影响生育率，维生素D与临床妊娠率无关。从长远来看，有更多关于维生素D的研究项目的空间。未来的研究可能包括对补充维生素D患者的病例对照研究，以及其与体外受精结果相关性的研究。
