巨噬细胞对环丙沙星的摄取。
Uptake of ciprofloxacin by macrophages.
作者信息
Easmon C S, Crane J P
出版信息
J Clin Pathol. 1985 Apr;38(4):442-4. doi: 10.1136/jcp.38.4.442.
Abstract
Ciprofloxacin was concentrated within mouse peritoneal macrophages to between two and three times extracellular values. Uptake was rapid, occurred equally well with dead cells, and was not affected by lowering the pH or by prior ingestion of Staphylococcus aureus. Intracellular staphylococci were killed by extracellular concentrations of ciprofloxacin as low as 0.5 mg/l.
摘要
环丙沙星在小鼠腹腔巨噬细胞内的浓度达到细胞外浓度的两到三倍。摄取迅速，死细胞摄取情况同样良好，降低pH值或预先摄入金黄色葡萄球菌均不影响摄取。细胞外浓度低至0.5毫克/升的环丙沙星就能杀死细胞内的葡萄球菌。
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