2%红霉素软膏治疗寻常痤疮的疗效评估。

An evaluation of a 2% erythromycin ointment in the topical therapy of acne vulgaris.

作者信息

Lesher J L, Chalker D K, Smith J G, Guenther L C, Ellis C N, Voorhees J J, Shalita A R, Klauda H C

出版信息

J Am Acad Dermatol. 1985 Mar;12(3):526-31. doi: 10.1016/s0190-9622(85)70074-6.

Abstract

Two hundred eight patients completed a 12-week, multicenter, double-blind, controlled study comparing a 2% erythromycin ointment to its vehicle. Patients were evaluated by inflammatory lesion counts and Cook acne severity grade at the initial visit and at weeks 2, 4, 8, 10, and 12. The 2% erythromycin ointment proved to be statistically more effective than the vehicle in reducing lesion counts and acne severity grade at weeks 4, 8, 10, and 12. The ointment caused few side effects and was well tolerated by most patients.

摘要

208名患者完成了一项为期12周的多中心、双盲对照研究，该研究比较了2%的红霉素软膏与其赋形剂。在初次就诊时以及第2、4、8、10和12周时，通过炎性皮损计数和库克痤疮严重程度分级对患者进行评估。在第4、8、10和12周时，2%的红霉素软膏在减少皮损计数和痤疮严重程度分级方面经统计学证明比赋形剂更有效。该软膏引起的副作用很少，大多数患者耐受性良好。