Human Performance Laboratory, Ball State University, Muncie, Indiana.
Department of Kinesiology and Health Promotion, University of Kentucky, Lexington, Kentucky, USA.
Curr Opin Clin Nutr Metab Care. 2019 Nov;22(6):459-464. doi: 10.1097/MCO.0000000000000598.
The purpose of this review is to provide a concise overview of the polyphenol curcumin for improving arterial health, specifically endothelial function and arterial stiffness, to reduce cardiovascular disease (CVD) risk and to highlight potential mechanisms of action by which curcumin may improve artery function.
The primary findings of this review support the notion for curcumin to improve arterial health both with aging and obesity. There are few clinical trials on curcumin, and those that currently exist are small in scale but provide evidence for curcumin to improve endothelial function in older adults and reduce arterial stiffness in young, obese men. The antioxidant and anti-inflammatory properties of curcumin appear to be important targets of curcumin that are related to improved arterial health. Mechanistic studies have revealed superoxide dismutase, heme oxygenase-1 and nuclear factor erythroid 2-related factor 2 as emerging targets for the beneficial effects of curcumin on the vasculature.
In summary, the efficacy of curcumin for improving arterial function is promising in the limited number of clinical studies performed to date. Still, much investigation is needed to elucidate the effectiveness of curcumin for improving arterial health to lower CVD risk.
目的综述：本文的目的是简要概述姜黄素在改善动脉健康方面的作用，特别是对内皮功能和动脉僵硬的作用，以降低心血管疾病（CVD）的风险，并强调姜黄素改善动脉功能的潜在作用机制。
最新发现：本综述的主要发现支持了姜黄素在衰老和肥胖状态下改善动脉健康的作用。目前关于姜黄素的临床试验较少，而现有的小规模临床试验提供了证据，表明姜黄素可改善老年人的内皮功能，降低年轻肥胖男性的动脉僵硬度。姜黄素的抗氧化和抗炎特性似乎是其改善动脉健康的重要靶点。机制研究表明，超氧化物歧化酶、血红素加氧酶-1 和核因子红细胞 2 相关因子 2 是姜黄素对血管有益作用的新兴靶点。
总结：总之，在目前已进行的有限数量的临床研究中，姜黄素改善动脉功能的疗效很有前景。但是，仍需要进一步的研究来阐明姜黄素在改善动脉健康、降低 CVD 风险方面的有效性。
