Wang Yizhi, Lu Jun, Jiang Bolun, Guo Junchao
Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, P.R. China.
Oncol Lett. 2020 Apr;19(4):3059-3070. doi: 10.3892/ol.2020.11437. Epub 2020 Mar 3.
Cancer is a harmful threat to human health. In addition to surgery, a variety of anticancer drugs are increasingly used in cancer therapy; however, despite the developments in multimodality treatment, the morbidity and mortality of patients with cancer patients are on the increase. The tumor-specific immunosuppressive microenvironment serves an important function in tumor tolerance and escape from immune surveillance leading to tumor progression. Therefore, identifying new drugs or foods that can enhance the tumor immune response is critical to develop improved cancer prevention methods and treatment. Curcumin, a polyphenolic compound extracted from ginger, has been shown to effectively inhibit tumor growth, proliferation, invasion, metastasis and angiogenesis in a variety of tumors. Recent studies have also indicated that curcumin can modulate the tumor immune response and remodel the tumor immunosuppressive microenvironment, indicating its potential in the immunotherapy of cancer. In this review, a brief introduction to the effects of curcumin on the tumor immune response and tumor immune microenvironment is provided and recent clinical trials investigating the potential of curcumin in cancer therapy are discussed.
癌症是对人类健康的有害威胁。除手术外，多种抗癌药物在癌症治疗中越来越常用；然而，尽管多模式治疗有所发展，但癌症患者的发病率和死亡率仍在上升。肿瘤特异性免疫抑制微环境在肿瘤耐受和逃避免疫监视从而导致肿瘤进展方面发挥着重要作用。因此，识别能够增强肿瘤免疫反应的新药或食物对于开发改进的癌症预防方法和治疗至关重要。姜黄素是从姜中提取的一种多酚化合物，已被证明能有效抑制多种肿瘤的生长、增殖、侵袭、转移和血管生成。最近的研究还表明，姜黄素可以调节肿瘤免疫反应并重塑肿瘤免疫抑制微环境，表明其在癌症免疫治疗中的潜力。在这篇综述中，简要介绍了姜黄素对肿瘤免疫反应和肿瘤免疫微环境的影响，并讨论了近期研究姜黄素在癌症治疗中潜力的临床试验。
