PHD 的底物。
Substrates of PHD.
机构信息
Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
出版信息
Cell Metab. 2019 Oct 1;30(4):626-627. doi: 10.1016/j.cmet.2019.08.008.
Abstract
The discovery of prolyl hydroxylase domain proteins (PHDs) as key enzymes in the hypoxia inducible factor (HIF) pathway has been followed by reports of a multitude of non-HIF substrates of PHD. Reporting in eLife, Cockman et al. (2019) find a surprising lack of detectable PHD activity toward any of them.
摘要
脯氨酰羟化酶结构域蛋白 (PHD) 的发现作为缺氧诱导因子 (HIF) 通路中的关键酶，随后有报道称 PHD 有多种非 HIF 底物。Cockman 等人在《eLife》杂志上报道（2019 年）发现，它们中没有任何一种可被检测到的 PHD 活性。
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