补骨脂素加紫外线A光疗法（PUVA疗法）期间外周血淋巴细胞功能的短暂损害

Transient impairment of peripheral blood lymphocyte function during PUVA therapy.

作者信息

Morison W L, Parrish J A, Bloch K J, Krugler J I

出版信息

Br J Dermatol. 1979 Oct;101(4):391-7. doi: 10.1111/j.1365-2133.1979.tb00016.x.

DOI:10.1111/j.1365-2133.1979.tb00016.x

Abstract

Three parameters of immune function--enumeration of circulating T and B lymphocytes and response of lymphocytes to graduated doses of phytohaemagglutinin (PHA)--were examined serially in eleven patients with psoriasis before, during, and after an intensive course of PUVA therapy. A trend was detected for the lymphocyte response to PHA to fall during the first week of treatment and then rise back towards the pre-treatment level. No alteration was found in the percentage or absolute numbers of circulating T and B lymphocytes. This study shows that routine PUVA therapy can induce an alteration in immune function but that this alteration is slight and short-lived.

摘要

在11例银屑病患者接受强化光化学疗法（PUVA）治疗前、治疗期间及治疗后，对免疫功能的三个参数——循环T淋巴细胞和B淋巴细胞计数以及淋巴细胞对不同剂量植物血凝素（PHA）的反应——进行了连续检测。在治疗的第一周，检测到淋巴细胞对PHA的反应呈下降趋势，随后又回升至治疗前水平。循环T淋巴细胞和B淋巴细胞的百分比或绝对数量未发现改变。本研究表明，常规PUVA治疗可引起免疫功能改变，但这种改变轻微且短暂。