Daneshbod-Skibba G, Shahidi N T, Becker G A, Martin J
Br J Haematol. 1979 Sep;43(1):7-14. doi: 10.1111/j.1365-2141.1979.tb03714.x.
Circulating T-lymphocytes from a 13-year-old boy with autoimmune anaemia, severe neutropenia and thrombocytopenia inhibited autologous and normal homologous bone marrow myeloid colony formation in vitro. This inhibition was abolished when the patient's antithymocyte globulin and complement-treated T-lymphocytes were used. T-lymphocytes from normal individuals did not cause such an inhibition. The patient's lymphocytes showed no inhibitory effect on erythroid colony formation. Investigation of the patient's serum failed to disclose any leucoagglutinin, lymphocytotoxin or humoral factor against myeloid colony formation. These findings indicate that T-lymphocytes may play a role in the pathogenesis of neutropenia in immune pancytopenia.
一名患有自身免疫性贫血、严重中性粒细胞减少症和血小板减少症的13岁男孩的循环T淋巴细胞在体外抑制了自体和正常同源骨髓髓系集落的形成。当使用患者经抗胸腺细胞球蛋白和补体处理的T淋巴细胞时，这种抑制作用被消除。正常个体的T淋巴细胞不会引起这种抑制作用。患者的淋巴细胞对红系集落形成没有抑制作用。对患者血清的研究未能发现任何针对髓系集落形成的白细胞凝集素、淋巴细胞毒素或体液因子。这些发现表明，T淋巴细胞可能在免疫性全血细胞减少症中性粒细胞减少症的发病机制中起作用。
