再生障碍性贫血患者中粒细胞生成的循环抑制因子。
Circulating inhibitors of granulopoiesis in patients with aplastic anaemia.
作者信息
Gordon M Y
出版信息
Br J Haematol. 1978 Aug;39(4):491-6. doi: 10.1111/j.1365-2141.1978.tb03618.x.
An inhibitor of granulopoiesis has been detected in the serum of aplastic patients by its ability to reduce colony formation by normal human marrow cells in culture. The inhibitory activity in the serum was abolished when a patient was treated with azathioprine and exposure of aplastic marrow to antithymocyte globulin (ATG) in vitro released the colony forming cells from suppression. The clinical findings in three of the patients studied support the idea that the inhibitory activity detected in vitro is associated with normal marrow suppression in vivo.
通过其降低正常人骨髓细胞在培养中集落形成的能力，在再生障碍性贫血患者的血清中检测到一种粒细胞生成抑制剂。当患者接受硫唑嘌呤治疗时，血清中的抑制活性消失，并且再生障碍性贫血骨髓在体外暴露于抗胸腺细胞球蛋白（ATG）可使集落形成细胞从抑制中释放出来。所研究的三名患者的临床发现支持了这样一种观点，即体外检测到的抑制活性与体内正常骨髓抑制有关。
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