Menitove J E, Rassiga A L, McLaren G D, Daniel T M, Mahmoud A A
Am J Hematol. 1981;10(3):277-84. doi: 10.1002/ajh.2830100307.
A phenytoin-associated serum-sickness-like syndrome was followed by severe pancytopenia in a 17-year-old female. Serum obtained during the acute phase of her illness contained antibodies against homologous eosinophils and neutrophils, antibodies against autologous neutrophils, and antibodies to phenytoin. The serum also inhibited bone marrow granulocyte colon formation in vitro. Lymphocyte transformation by pokeweed mitogen was impaired and, after recovery, the patient's lymphocytes were transformed in vitro by the addition of phenytoin. These data demonstrate that profound derangements of immunity can be associated with a phenytoin-induced serum-sickness-like illness.
一名17岁女性在出现苯妥英钠相关的血清病样综合征后，继而发生严重全血细胞减少。在其疾病急性期采集的血清中含有抗同源嗜酸性粒细胞和中性粒细胞的抗体、抗自体中性粒细胞的抗体以及抗苯妥英钠的抗体。该血清在体外也抑制骨髓粒细胞集落形成。商陆有丝分裂原诱导的淋巴细胞转化受损，恢复后，添加苯妥英钠可使患者的淋巴细胞在体外发生转化。这些数据表明，免疫功能的严重紊乱可能与苯妥英钠诱导的血清病样疾病有关。
