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16天内新发水疱性动脉瘤形成与毛霉目真菌有关。

De Novo Blister Aneurysm Formation in 16 Days Associated with Mucorales Fungi.

作者信息

Thind Harjot, Waldau Ben

机构信息

Neurological Surgery, University of California Davis Medical Center, Sacramento, USA.

Neurological Surgery, University of California, Davis Medical Center, Sacramento, USA.

出版信息

Cureus. 2019 Aug 1;11(8):e5301. doi: 10.7759/cureus.5301.

DOI:10.7759/cureus.5301
PMID:31579640
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6768621/
Abstract

Although blister aneurysms represent a small percentage of all intracranial aneurysms, they are generally considered to be a more morbid and challenging entity than the more common saccular intracranial aneurysms. Despite this, the etiology of blister aneurysms is still unknown, though there are several theories. We present the case of a 54-year-old man who initially presented with vision loss and normal intracranial computed tomography angiography imaging. Only 16 days thereafter, he underwent rapidly progressive clinical decline, which was found to be due to the development and rupture of a de novo supraclinoidal blister aneurysm. Autopsy results showed fungal infection of the arterial wall by Mucorales fungi at the site of the aneurysm. Our case report supports the theory that blister aneurysms can be caused by fungal infection of the wall of the internal carotid artery.

摘要

尽管水泡状动脉瘤在所有颅内动脉瘤中占比很小,但与更常见的囊状颅内动脉瘤相比,它们通常被认为是更具病态且更具挑战性的病变。尽管如此,水泡状动脉瘤的病因仍然不明,不过有几种理论。我们报告一例54岁男性病例,该患者最初表现为视力丧失,颅内计算机断层血管造影成像正常。仅16天后,他的临床症状迅速进展性恶化,结果发现是由于一个新出现的鞍上水泡状动脉瘤形成并破裂所致。尸检结果显示,动脉瘤部位的动脉壁被毛霉目真菌真菌感染。我们的病例报告支持这样一种理论,即水泡状动脉瘤可能由颈内动脉壁的真菌感染引起。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f18/6768621/56d9b921b2f0/cureus-0011-00000005301-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f18/6768621/56d9b921b2f0/cureus-0011-00000005301-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f18/6768621/56d9b921b2f0/cureus-0011-00000005301-i01.jpg

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本文引用的文献

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Blister Aneurysms of the Internal Carotid Artery: Microsurgical Results and Management Strategy.颈内动脉泡状动脉瘤:显微手术结果与治疗策略
Neurosurgery. 2017 Feb 1;80(2):235-247. doi: 10.1227/NEU.0000000000001259.
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Retrospective Clinical Study of Eighty-One Cases of Intracranial Mucormycosis.81例颅内毛霉菌病的回顾性临床研究
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A Systematic Review and Meta-Analysis of Treatment and Outcome of Blister-Like Aneurysms.泡状动脉瘤治疗与结局的系统评价和Meta分析
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Morphological aspects of blister aneurysms and nuances for surgical treatment.水泡状动脉瘤的形态学特征及手术治疗的细微差别。
J Neurosurg. 2015 Nov;123(5):1156-65. doi: 10.3171/2014.11.JNS141004. Epub 2015 May 22.
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Internal carotid artery blister-like aneurysm caused by Aspergillus - case report.曲霉菌引起的颈内动脉泡状动脉瘤——病例报告
Pol J Radiol. 2015 Mar 25;80:159-63. doi: 10.12659/PJR.893050. eCollection 2015.
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N Engl J Med. 2014 Jul 10;371(2):150-60. doi: 10.1056/NEJMra1216008.
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Blood blister-like aneurysms: single center experience and systematic literature review.血疱样动脉瘤:单中心经验和系统文献回顾。
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Long-term follow-up of blister aneurysms of the internal carotid artery.颈内动脉囊状动脉瘤的长期随访。
Neurosurgery. 2013 Dec;73(6):1026-33; discussion 1033. doi: 10.1227/NEU.0000000000000147.
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Rhinocerebral mucormycosis: An analysis of probable mode of spread and its implication in an early diagnosis and treatment.鼻脑型毛霉菌病:可能的传播方式分析及其在早期诊断和治疗中的意义
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Blister-like aneurysms--a diagnostic and therapeutic challenge.疱状动脉瘤——诊断与治疗的挑战。
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