Gonzalez Lindh Margareta, Malinovschi Andrei, Brandén Eva, Janson Christer, Ställberg Björn, Bröms Kristina, Blom Johansson Monica, Lisspers Karin, Koyi Hirsh
Centre for Research and Development, Uppsala University/Region Gävleborg, Gävle, Sweden.
Dept of Neuroscience, Uppsala University, Uppsala, Sweden.
ERJ Open Res. 2019 Sep 25;5(3). doi: 10.1183/23120541.00081-2019. eCollection 2019 Jul.
This study aimed to investigate the prevalence of subjective ( self-reported) swallowing symptoms in a large cohort of patients with stable chronic obstructive pulmonary disease (COPD) and to identify potential related risk factors.
A total of 571 patients with COPD, investigated in a stable phase, participated in this multicentre study (335 females, 236 males; mean age: 68.6 years (sd 7.7)). Data were derived from spirometry, a questionnaire and a 30-metre walking test.
In total, 33% (n=186) patients reported at least some degree of swallowing problem. The most frequently reported symptom was food lodging in the throat (23%). A significant relationship was found between swallowing symptoms and dyspnoea, assessed as modified Medical Research Council (mMRC) ≥2 compared with <2 (46% 22%; p<0.001) and health-related quality of life, assessed as the COPD Assessment Test (CAT) ≥10 (40% 19%; p<0.001). Swallowing problems were also related to lower physical capacity (p=0.02) but not to lung function (p>0.28).
Subjective swallowing symptoms seem to be a common problem in patients with stable COPD. This problem is seen in all stages of the disease, but is more common in symptomatic patients and in patients with lower physical capacity.
本研究旨在调查一大群稳定期慢性阻塞性肺疾病（COPD）患者主观（自我报告）吞咽症状的患病率，并确定潜在的相关危险因素。
共有571名处于稳定期的COPD患者参与了这项多中心研究（335名女性，236名男性；平均年龄：68.6岁（标准差7.7））。数据来自肺活量测定、问卷调查和30米步行测试。
总计33%（n = 186）的患者报告至少有一定程度的吞咽问题。最常报告的症状是食物卡在喉咙里（23%）。发现吞咽症状与呼吸困难之间存在显著关系，以改良医学研究委员会（mMRC）≥2与<2进行评估时（分别为46%和22%；p<0.001），以及与健康相关生活质量之间存在显著关系，以慢性阻塞性肺疾病评估测试（CAT）≥10进行评估时（分别为40%和19%；p<0.001）。吞咽问题也与身体能力较低有关（p = 0.02），但与肺功能无关（p>0.28）。
主观吞咽症状似乎是稳定期COPD患者的常见问题。这个问题在疾病的各个阶段都可见，但在有症状的患者和身体能力较低的患者中更常见。
