甲硝唑耐药阴道毛滴虫
Metronidazole-resistant Trichomonas vaginalis.
作者信息
Forsgren A, Forssman L
出版信息
Br J Vener Dis. 1979 Oct;55(5):351-3. doi: 10.1136/sti.55.5.351.
Abstract
A 36-year-old woman with symptomatic metronidazole-resistant trichomonal vaginitis for 10 years had a total of 22 courses of treatment with either metronidazole or tinidazole according to different schedules. The minimum trichomonicidal concentration of metronidazole for the strain of Trichomonas vaginalis isolated from the patient was 160 microgram/ml compared with 1.25-10 microgram/ml for other freshly isolated strains. The former strain also showed a definitely decreased sensitivity to ornidazole and tinidazole (80 microgram/ml). The mechanisms behind the appearance of resistance in this clinical isolate are at present unknown and require further study from the theoretical as well as the therapeutic viewpoint.
摘要
一名36岁患有症状性甲硝唑耐药滴虫性阴道炎10年的女性，根据不同方案，先后接受了共计22个疗程的甲硝唑或替硝唑治疗。从该患者分离出的阴道毛滴虫菌株对甲硝唑的最低杀滴虫浓度为160微克/毫升，而其他新分离菌株的该浓度为1.25 - 10微克/毫升。前一种菌株对奥硝唑和替硝唑（80微克/毫升）的敏感性也明显降低。目前尚不清楚该临床分离株耐药出现的机制，从理论和治疗角度都需要进一步研究。
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