Kulda J, Vojtĕchovská M, Tachezy J, Demes P, Kunzová E
Br J Vener Dis. 1982 Dec;58(6):394-9. doi: 10.1136/sti.58.6.394.
Six isolates of a strain (MRP-MT) of Trichomonas vaginalis obtained from a woman before and after unsuccessful treatment with metronidazole had an appreciably lower susceptibility to metronidazole both in vitro in the aerobic tube assay and in vivo in the mouse assay than did control strains from patients cured with standard doses of the drug. Our results support recent evidence that metronidazole-resistant strains of T vaginalis do cause treatment failure. Resistance of these strains could be detected in vitro under only aerobic but not anaerobic conditions. The prevalence of metronidazole-resistant strains of T vaginalis should be kept under surveillance in order to estimate their clinical importance. The patient harbouring the resistant strain MRP-MT was finally cured with increased doses of ornidazole.
从一名女性患者身上分离出的一株阴道毛滴虫（MRP-MT），在甲硝唑治疗失败前后进行培养，其在需氧管试验中的体外甲硝唑敏感性以及在小鼠试验中的体内甲硝唑敏感性，均明显低于用标准剂量该药物治愈的患者所分离出的对照菌株。我们的研究结果支持了最近的证据，即甲硝唑耐药的阴道毛滴虫菌株确实会导致治疗失败。这些菌株的耐药性仅在需氧而非厌氧条件下才能在体外检测到。为了评估其临床重要性，应持续监测阴道毛滴虫甲硝唑耐药菌株的流行情况。携带耐药菌株MRP-MT的患者最终通过增加奥硝唑剂量得以治愈。
