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实验性低血容量期间猪体内纤溶酶原激活物活性和纤溶酶抑制作用的变化

Changes in plasminogen activator activity and plasmin inhibition in the pig during experimental hypovolaemia.

作者信息

Smokovitis A, Wagner M, Starlinger M, Opitz A, Binder B R

出版信息

Thromb Haemost. 1985 Feb 18;53(1):130-3.

PMID:3158093
Abstract

A markedly decreased plasminogen activator activity (PAA) was seen in lung, heart and kidney after experimental hypovolemia in the pig. In 2 of 12 cases, an increased PAA was found in liver and spleen. In skeletal muscle, skin, sciatic nerve and in 10 of 12 cases in liver and spleen PAA was unchanged. A slightly increased plasmin inhibition was noted only in the lung. These changes in tissue PAA were reflected by an increase in the PAA of euglobulin fractions concomitant with a decrease in antiplasmin activity in the blood samples obtained during the bleeding experiments.

摘要

在猪实验性低血容量后,肺、心脏和肾脏中的纤溶酶原激活物活性(PAA)明显降低。在12例中的2例中,肝脏和脾脏中的PAA增加。在骨骼肌、皮肤、坐骨神经以及12例中的10例肝脏和脾脏中,PAA未发生变化。仅在肺中观察到纤溶抑制略有增加。这些组织PAA的变化反映在优球蛋白组分的PAA增加,同时在出血实验期间采集的血样中抗纤溶酶活性降低。

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