The effect of the anabolic steroid stanozolol on tissue plasminogen activator activity and plasmin inhibition in the rat.

The anabolic steroid stanozolol administered orally in male Sprague-Dawley rats induced a dose- and time-dependent increase in tissue plasminogen activator activity. The increase was highest in lung, lowest in heart, and intermediate in aorta and kidney. A slight increase in plasmin inhibition was noted only in the heart.