Emma Children's Hospital, Amsterdam UMC, Pediatric Endocrinology, Vrije Universiteit Amsterdam, (1000-1183) Amsterdam, The Netherlands.
Department of Paediatric Endocrinology, Obesity Center CGG, Sophia Children's Hospital, (3000-3099) Rotterdam, The Netherlands.
Nutrients. 2019 Oct 2;11(10):2351. doi: 10.3390/nu11102351.
Glucocorticoids (GCs) in breastmilk have previously been associated with infant body growth and body composition. However, the diurnal rhythm of breastmilk GCs was not taken into account, and we therefore aimed to assess the associations between breastmilk GC rhythmicity at 1 month and growth and body composition at 3 months in infants.
At 1 month postpartum, breastmilk GCs were collected over a 24-h period and analyzed by LC-MS/MS. Body composition was measured using air-displacement plethysmography at 3 months. Length and weight were collected at 1, 2, and 3 months.
In total, 42 healthy mother-infant pairs were included. No associations were found between breastmilk GC rhythmicity (area-under-the-curve increase and ground, maximum, and delta) and infant growth trajectories or body composition (fat and fat free mass index, fat%) at 3 months.
This study did not find an association between breastmilk GC rhythmicity at 1 month and infant's growth or body composition at 3 months. Therefore, this study suggests that previous observations linking breastmilk cortisol to changes in infant weight might be flawed by the lack of serial cortisol measurements and detailed information on body composition.
母乳中的糖皮质激素（GCs）先前与婴儿的身体生长和身体成分有关。然而，并未考虑母乳 GCs 的昼夜节律，因此，本研究旨在评估 1 个月时母乳 GC 节律性与 3 个月时婴儿生长和身体成分之间的关系。
产后 1 个月时，通过 LC-MS/MS 对 24 小时内的母乳 GCs 进行采集，并进行分析。3 个月时，采用空气置换体描记法测量身体成分。1、2 和 3 个月时分别采集长度和体重。
共纳入 42 对健康母婴。1 个月时母乳 GC 节律性（曲线下面积增加、基础值、最大值和差值）与 3 个月时婴儿的生长轨迹或身体成分（脂肪和去脂体重指数、脂肪%）之间无关联。
本研究未发现 1 个月时母乳 GC 节律性与 3 个月时婴儿生长或身体成分之间存在关联。因此，本研究表明，之前观察到母乳皮质醇与婴儿体重变化有关的结果可能存在缺陷，因为缺乏皮质醇的连续测量以及身体成分的详细信息。
