Romijn Michelle, van Tilburg Luca J L, Hollanders Jonneke J, van der Voorn Bibian, de Goede Paul, Dolman Koert M, Heijboer Annemieke C, Broekman Birit F P, Rotteveel Joost, Finken Martijn J J
Department of Pediatric Endocrinology, Emma Children's Hospital, Amsterdam University Medical Centers, location VUmc, 1081 HV Amsterdam, The Netherlands.
Department of Pediatrics, Amsterdam Reproduction & Development Research Institute, Vrije Universiteit Amsterdam, Amsterdam UMC, 1081 HV Amsterdam, The Netherlands.
Nutrients. 2021 May 11;13(5):1608. doi: 10.3390/nu13051608.
Chronic stress is often accompanied by alterations in the diurnal rhythm of hypothalamus-pituitary-adrenal activity. However, there are limited data on the diurnal rhythmicity of breast milk glucocorticoids (GCs) among women with psychological distress. We compared mothers who sought consultation at an expertise center for pregnant women with an increased risk of psychological distress with control mothers for GC diurnal rhythmicity in milk and saliva obtained at the same time.
We included 19 mothers who sought consultation at the psychiatry-obstetric-pediatric (POP) outpatient clinic and 44 control mothers. One month postpartum, mothers collected on average eight paired milk and saliva samples during a 24 h period. GC levels were measured using liquid chromatography-tandem mass spectrometry. GC rhythmicity parameters were determined with specialized software.
For both milk and saliva, no group differences regarding GC rhythms were found. Milk cortisol area under the curve with respect to the ground was lower in the POP group than in the control group ( = 0.02). GC levels in human milk and saliva were highly correlated within each group ( < 0.001).
Although there were no differences between groups in GC rhythmicity, the total amount of milk cortisol was lower in the POP group. Long-term follow-up is needed to address the impact of vertical transmission of breast milk GCs.
慢性应激常伴有下丘脑 - 垂体 - 肾上腺活动昼夜节律的改变。然而，关于心理困扰女性母乳中糖皮质激素（GCs）昼夜节律性的数据有限。我们将在一个针对心理困扰风险增加的孕妇专业中心寻求咨询的母亲与对照母亲进行比较，以研究同时采集的母乳和唾液中GC的昼夜节律性。
我们纳入了19名在精神科 - 产科 - 儿科（POP）门诊寻求咨询的母亲和44名对照母亲。产后1个月，母亲们在24小时内平均采集8对母乳和唾液样本。使用液相色谱 - 串联质谱法测量GC水平。用专门软件确定GC节律性参数。
对于母乳和唾液，未发现两组在GC节律方面存在差异。POP组相对于基线的母乳皮质醇曲线下面积低于对照组（ = 0.02）。每组中母乳和唾液中的GC水平高度相关（ < 0.001）。
虽然两组在GC节律性方面没有差异，但POP组母乳皮质醇总量较低。需要进行长期随访以研究母乳GC垂直传播的影响。
