Department of Occupational and Environmental Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
Department of Occupational and Environmental Medicine, College of Medicine, Hanyang University, Seoul, Republic of Korea.
Chronobiol Int. 2019 Dec;36(12):1671-1680. doi: 10.1080/07420528.2019.1670671. Epub 2019 Oct 3.
There is no study on the relationship between working hours and nonalcoholic fatty liver disease (NAFLD). The objective of the present study was to determine the relationship between working hours and NAFLD by sleep duration using a large set of abdominal ultrasonography examination data. Data from 194,625 patients who underwent health examinations from 2015 to 2017 were analyzed. Chi-square tests, linear-by-linear association and ANOVA were performed to compare general characteristics according to working hours. Multivariate logistic regression analysis was performed to determine the relationship between working hours and NAFLD by sleep duration. There was no significant relationship between working hours and NAFLD prevalence in the group of short sleep duration of ≤5 hours or the group of long sleep duration of ≥7 hours. The risk of NAFLD in the >52 working hour group was significantly higher (aOR, 1.09; 95% CI, 1.04-1.14) than that in the 40- to 52-hour working hour group after adjusting for confounding factors in the 5- to 6-hour sleep duration group. There was no significant difference between ≤40 working hours and 40 ~ 52 working hours in the 5 ~ 6 hours sleep duration group (aOR, 1.02; 95% CI, 0.97-1.06). In general, working hours were significantly related to NAFLD. There was a difference in the relationship between working hours and NAFLD according to sleep duration.
目前尚无关于工作时间与非酒精性脂肪性肝病（NAFLD）之间关系的研究。本研究旨在通过睡眠时长利用大量腹部超声检查数据来确定工作时间与 NAFLD 之间的关系。分析了 2015 年至 2017 年期间接受健康检查的 194625 名患者的数据。通过卡方检验、线性关联和方差分析比较了根据工作时间的一般特征。通过多变量逻辑回归分析，确定了睡眠时间与 NAFLD 之间的关系。在睡眠时间≤5 小时或睡眠时间≥7 小时的组中，工作时间与 NAFLD 患病率之间没有显著关系。与 40 至 52 小时工作时间组相比，>52 小时工作时间组的 NAFLD 风险显著更高（aOR，1.09；95%CI，1.04-1.14），在 5 至 6 小时睡眠时间组中调整了混杂因素后。在 5 至 6 小时睡眠时间组中，≤40 小时和 40 至 52 小时之间的工作时间没有显著差异（aOR，1.02；95%CI，0.97-1.06）。一般来说，工作时间与 NAFLD 显著相关。工作时间与 NAFLD 之间的关系因睡眠时间而异。
