School of Materials Science and Engineering, The Key Laboratory of Advanced Ceramics and Machining Technology by the Ministry of Education of China, Tianjin University, 300072, Tianjin, China.
Ministry-of-Education Key Laboratory for the Green Preparation and Application of Functional Materials, Hubei Key Laboratory of Polymer Materials, School of Materials Science and Engineering, Hubei University, 430062, Wuhan, China.
Nat Commun. 2019 Oct 3;10(1):4490. doi: 10.1038/s41467-019-12429-6.
The application of photothermal therapy to treat bacterial infections remains a challenge, as the high temperatures required for bacterial elimination can damage healthy tissues. Here, we develop an exogenous antibacterial agent consisting of zinc-doped Prussian blue (ZnPB) that kills methicillin-resistant Staphylococcus aureus in vitro and in a rat model of cutaneous wound infection. Local heat triggered by the photothermal effect accelerates the release and penetration of ions into the bacteria, resulting in alteration of intracellular metabolic pathways and bacterial killing without systemic toxicity. ZnPB treatment leads to the upregulation of genes involved in tissue remodeling, promotes collagen deposition and enhances wound repair. The efficient photothermal conversion of ZnPB allows the use of relatively few doses and low laser flux, making the platform a potential alternative to current antibiotic therapies against bacterial wound infections.
光热疗法在治疗细菌感染方面仍然是一个挑战，因为消除细菌所需的高温会对健康组织造成损害。在这里，我们开发了一种由锌掺杂普鲁士蓝（ZnPB）组成的外源性抗菌剂，该抗菌剂能够在体外和皮肤伤口感染的大鼠模型中杀死耐甲氧西林金黄色葡萄球菌。光热效应引发的局部热加速了离子向细菌的释放和渗透，导致细胞内代谢途径的改变和细菌的杀灭，而没有全身毒性。ZnPB 处理导致参与组织重塑的基因上调，促进胶原蛋白沉积并增强伤口修复。ZnPB 的高效光热转换允许使用相对较少的剂量和低激光通量，使该平台成为当前治疗细菌性伤口感染的抗生素疗法的潜在替代方法。
