Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
J Bone Miner Metab. 2020 Jan;38(1):7-13. doi: 10.1007/s00774-019-01048-2. Epub 2019 Oct 3.
Sarcopenia is an age-related loss of skeletal muscle mass and strength. It has been widely recognized that low muscle mass was essential in the diagnosis of sarcopenia, whereas recent studies have emphasized the importance of muscle strength. In practice, muscle quality as well as muscle mass might determine the strength and physical performance. A new diagnostic algorithm of sarcopenia has recently been established, in which low muscle strength is a key characteristic factor for the diagnosis of sarcopenia. Although many factors are supposed to be involved in the pathology and development of sarcopenia, precise mechanisms remain to be elucidated. Recent studies have also focused on the crosstalk between muscles and bones, including functional involvement of myokines and osteokines.
肌肉减少症是一种与年龄相关的骨骼肌量和力量损失。人们普遍认为，低肌肉量是肌肉减少症诊断的关键，而最近的研究则强调了肌肉力量的重要性。实际上，肌肉质量以及肌肉量可能决定了力量和身体机能。最近已经建立了一种新的肌肉减少症诊断算法，其中肌肉力量低是诊断肌肉减少症的关键特征因素。尽管许多因素被认为与肌肉减少症的病理和发展有关，但确切的机制仍有待阐明。最近的研究还集中在肌肉和骨骼之间的相互作用上，包括肌肉因子和骨因子的功能参与。
