Maalouf George-Emmanuel, El Khoury Diala
Department of Sciences, Notre Dame University-Louaize, P.O. Box 72, Zouk Mikael, Lebanon.
J Obes. 2019 Apr 1;2019:6561726. doi: 10.1155/2019/6561726. eCollection 2019.
Irisin is a recently discovered myokine that plays an important role in fat metabolism through the browning of white adipose tissue. This myokine is usually secreted after exercise by improving energy balance and has shown great potential as a possible treatment for some metabolic diseases such as obesity, insulin resistance, and inflammation. Obesity has been linked to a higher incidence of some cancers. Furthermore, some studies have shown irisin to have direct positive effects on different types of cancers. Although it is hard to relay conclusions from to studies, the majority of the available data favor irisin as a potential substance for cancer regression through reducing proinflammatory markers linked to obesity. However, some controversies remain on the exact benefits of irisin on cancer with some studies showing no or even a negative effect of irisin on cancer. This review summarizes these 2 differing viewpoints and synthesizes them to form a clearer picture of exercise-induced irisin's effects on cancer.
鸢尾素是一种最近发现的肌动蛋白，通过白色脂肪组织的褐变在脂肪代谢中发挥重要作用。这种肌动蛋白通常在运动后通过改善能量平衡而分泌，并且作为治疗某些代谢疾病（如肥胖、胰岛素抵抗和炎症）的可能疗法已显示出巨大潜力。肥胖与某些癌症的较高发病率有关。此外，一些研究表明鸢尾素对不同类型的癌症有直接的积极影响。尽管很难从这些研究中得出结论，但大多数现有数据支持鸢尾素作为一种潜在物质，通过减少与肥胖相关的促炎标志物来实现癌症消退。然而，关于鸢尾素对癌症的确切益处仍存在一些争议，一些研究表明鸢尾素对癌症没有影响甚至有负面影响。本综述总结了这两种不同观点，并将它们综合起来，以更清晰地呈现运动诱导的鸢尾素对癌症的影响。
