Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar, India.
Postgraduate and Research Department of Biochemistry, Government Arts College For Women, Krishnagiri, India.
Arch Physiol Biochem. 2022 Feb;128(1):148-162. doi: 10.1080/13813455.2019.1669057. Epub 2019 Oct 4.
Beta-caryophyllene (BCP), are natural bicyclic sesquiterpenes which are present in numerous plants worldwide. BCP has antioxidant, antimicrobial, and antifungal properties. Here, we studied its anticancer, anti-inflammatory, and cytotoxic effects. Cells treated with BCP, in a dose-dependent manner, exhibited morphological changes, showed lower cell growth, underwent apoptosis and lost the ability to metastasis through the suppression of NF-ҡ B via PI3K/AKT signalling pathway. These results elucidate that the inhibition of NF-ҡ B and PI3K/AKT is one of the most important mechanism by which BCP suppresses cancer cell proliferation and enhances apoptosis.
β-石竹烯（BCP）是存在于世界上众多植物中的天然双环倍半萜烯。BCP 具有抗氧化、抗菌和抗真菌特性。在这里，我们研究了它的抗癌、抗炎和细胞毒性作用。以剂量依赖性方式用 BCP 处理的细胞表现出形态变化，显示出较低的细胞生长，通过抑制 NF-ҡ B 经 PI3K/AKT 信号通路发生细胞凋亡并丧失转移能力。这些结果表明，抑制 NF-ҡ B 和 PI3K/AKT 是 BCP 抑制癌细胞增殖和增强细胞凋亡的最重要机制之一。
