Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Department of Physiology and Pharmacology, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
Nutr Neurosci. 2021 Sep;24(9):674-687. doi: 10.1080/1028415X.2019.1668173. Epub 2019 Oct 4.
The effects of hydroalcoholic extract of () on memory changes, as well as lung injury due to inhaled paraqut (PQ) in rat, were examined. Control group of rat with saline aerosol administration, PQ groups with PQ aerosol (27 and 54 mg/m) administration, PQ groups treated with two doses of the extract (200 and 800 mg/kg/day) and dexamethasone (0.03 mg/kg/day) were studied. Shuttle box and Morris Water Maze (MWM) tests were carried out as well as oxidant, anti-oxidant markers, total and differential white blood cell (WBC) counts and cytokine levels in broncho-alveolar lavage (BALF). Inhaled PQ significantly increased the escape latency and travelled distance in MWM test, but the time spent in the target quadrant on the probe day was significantly reduced ( < 0.05 to p < 0.001). The latency to enter the dark room at 3, 24, and 48 h after an electrical shock was reduced due to PQ ( < 0.05 to < 0.001). Exposure to PQ significantly increased total WBC, neutrophil, eosinophil, lymphocyte, and monocyte counts, IL-10, interferon gama (INF-γ), nitrite (NO), and malondialdehyde (MDA) levels, but catalase (CAT), superoxide dismutase (SOD), and thiol levels were decreased ( < 0.05 to < 0.00). and dexamethasone treatment significantly improved all behavioral as well as lung changes induced by inhaled PQ ( < 0.05 to < 0.01). treatment improved learning and memory impairment as well as lung inflammation and oxidative stress induced by inhaled PQ.
研究了 () 的水醇提取物对吸入对硫磷（PQ）引起的大鼠记忆改变和肺损伤的影响。生理盐水气雾剂给药的对照组大鼠、PQ 气雾剂（27 和 54mg/m）给药的 PQ 组、给予两种剂量提取物（200 和 800mg/kg/天）和地塞米松（0.03mg/kg/天）的 PQ 组进行了研究。进行了穿梭箱和莫里斯水迷宫（MWM）测试以及氧化应激、抗氧化标志物、支气管肺泡灌洗液（BALF）中的总白细胞和白细胞分类计数以及细胞因子水平的检测。吸入 PQ 显著增加了 MWM 测试中的逃避潜伏期和行驶距离，但在探测日花费在目标象限的时间明显减少（<0.05 至 <0.001）。由于 PQ，电击后 3、24 和 48 小时进入暗室的潜伏期缩短（<0.05 至 <0.001）。接触 PQ 显著增加了总白细胞、中性粒细胞、嗜酸性粒细胞、淋巴细胞和单核细胞计数、白细胞介素-10（IL-10）、干扰素 gama（INF-γ）、亚硝酸盐（NO）和丙二醛（MDA）水平，但过氧化氢酶（CAT）、超氧化物歧化酶（SOD）和巯基水平降低（<0.05 至 <0.00）。和地塞米松治疗显著改善了吸入 PQ 引起的所有行为和肺部变化（<0.05 至 <0.01）。治疗改善了吸入 PQ 引起的学习和记忆障碍以及肺炎症和氧化应激。
