From the Rheumatology Division - Universidade Federal de São Paulo - Escola Paulista de Medicina - Sao Paulo, Sao Paulo, Brazil.
Am J Phys Med Rehabil. 2019 Oct;98(10):872-878. doi: 10.1097/PHM.0000000000001217.
The aim of the study was to assess the time effect of intra-articular injection with triamcinolone hexacetonide in rheumatic patients.
A prospective case-control study with patients submitted to one intra-articular injection with triamcinolone hexacetonide. Patients were followed monthly (12 mos) for pain and swelling.
Two hundred sixty-two joints were assessed in 158 patients with mean ± SD age of 60 ± 13.7 yrs. Remission was observed at 3, 6, and 12 mos in 142 (54.19%), 111 (42.36%), and 105 (40.07%) joints, respectively. The mean ± SD time effect were 8 ± 4.0 mos; 8.4 ± 3.9 for rheumatoid arthritis patients and 6.9 ± 4.0 for osteoarthritis patients (P = 0.012) and 10.4 ± 2.7 mos for small, 7.7 ± 4.1 for medium, and 6.8 ± 4.0 for large joints. The joints were divided into two groups: long-term group (time effect of intra-articular injection longer than 6 mos) and short-term group. The following are the variables associated (P < 0.05) with long-term group: rheumatoid arthritis, small and medium-sized joints, female sex, lower pain and swelling visual analog scale scores, and use of leflunomide. The following are the variables associated with short-term group: receiving only one intra-articular injection, hypertension, diabetes mellitus, and biological therapy.
The mean ± SD time effect of intra-articular injection with triamcinolone hexacetonide was 8.0 ± 4.0 mos. The associated predictors were rheumatoid arthritis, small and medium joints, lower pain/swelling visual analog scale scores, and use of leflunomide.
本研究旨在评估关节内注射曲安奈德对风湿患者的时间效应。
前瞻性病例对照研究，患者接受单次关节内注射曲安奈德。患者每月（12 个月）随访，评估疼痛和肿胀情况。
158 例患者的 262 个关节接受评估，平均年龄±标准差为 60±13.7 岁。在 3、6 和 12 个月时，分别有 142（54.19%）、111（42.36%）和 105（40.07%）个关节达到缓解。平均±标准差时间效应分别为 8±4.0 个月；类风湿关节炎患者为 8.4±3.9 个月，骨关节炎患者为 6.9±4.0 个月（P=0.012）；小关节为 10.4±2.7 个月，中关节为 7.7±4.1 个月，大关节为 6.8±4.0 个月。关节分为两组：长期组（关节内注射时间效应长于 6 个月）和短期组。与长期组相关的变量（P<0.05）包括：类风湿关节炎、小关节和中关节、女性、较低的疼痛和肿胀视觉模拟评分、以及使用来氟米特。与短期组相关的变量包括：仅接受一次关节内注射、高血压、糖尿病和生物治疗。
关节内注射曲安奈德的平均±标准差时间效应为 8.0±4.0 个月。相关预测因素包括类风湿关节炎、小关节和中关节、较低的疼痛/肿胀视觉模拟评分以及来氟米特的使用。
