Division of vector control, Entomology Research Institute, Loyola College, Chennai, Tamil Nadu, 600034, India.
Center of Advanced Study in Crystallography and Biophysics, University of Madras, Chennai, Tamil Nadu, 600 025, India.
Front Biosci (Elite Ed). 2020 Jan 1;12(1):1-34. doi: 10.2741/E855.
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that causes memory and cognitive deficits. The present study was carried out to evaluate the protective effects of fucoidan in monocrotophos induced AD in Drosophila melanogaster. In silico studies showed that fucoidan exhibited binding energy of -9.3 kcal with proteins. Consistent with this, fucoidan, in a dose and time-dependent fashion, had inhibitory activity against cholinergic and monoamine-metabolized enzymes in vitro. Fucoidan inhibited the increase in total mRNA and protein in monocrotophos fed flies and prevented changes in biochemicals, neurochemicals and latency time of locomotor, learning and memory induced by monocrotophos. Together, the findings show that fucoidan serves a neuroprotective effect in Alzheimer's disease model in D. melanogaster.
阿尔茨海默病（AD）是一种进行性神经退行性疾病，可导致记忆和认知功能障碍。本研究旨在评估褐藻糖胶在滴滴涕诱导的黑腹果蝇 AD 模型中的保护作用。 计算机模拟研究表明，褐藻糖胶与蛋白质具有 -9.3 kcal 的结合能。 与这一结果一致的是，褐藻糖胶以剂量和时间依赖的方式在体外抑制胆碱能和单胺代谢酶的活性。 褐藻糖胶抑制了滴滴涕喂养的果蝇中总 mRNA 和蛋白质的增加，并防止了滴滴涕引起的生化、神经化学和运动、学习和记忆潜伏期的变化。 综上所述，这些发现表明褐藻糖胶在黑腹果蝇的阿尔茨海默病模型中具有神经保护作用。
