Department of Cell and Molecular Biology, Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal-576104, Karnataka, India.
Department of Cell and Molecular Biology, Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal-576104, Karnataka, India,
Front Biosci (Elite Ed). 2020 Jan 1;12(1):48-78. doi: 10.2741/E857.
Epithelial to mesenchymal transition (EMT) is a multistep biological process in which epithelial cells acquire characteristics of mesenchymal cells. Inappropriate activation of EMT contributes to the acquisition of pro-metastatic characteristics and cancer progression. EMT process involves the downregulation of epithelial markers () and upregulation of mesenchymal markers () and EMT-transcription factors (). MicroRNAs, a class of non-coding RNA post-transcriptionally govern gene expression by binding to the target mRNAs. A large proportion of miRNAs occur as miRNA clusters consisting of two or more miRNA coding genes. MiRNA clusters are reported to regulate diverse biological functions, including EMT. This comprehensive review discusses the role of miRNA clusters in EMT.
上皮间质转化（EMT）是上皮细胞获得间充质细胞特征的多步骤生物学过程。EMT 的异常激活有助于获得促转移特征和癌症进展。EMT 过程涉及上皮标志物（）的下调和间充质标志物（）和 EMT 转录因子（）的上调。miRNA 是一类非编码 RNA，通过与靶 mRNA 结合在后转录水平上调控基因表达。很大一部分 miRNA 作为包含两个或更多 miRNA 编码基因的 miRNA 簇出现。据报道，miRNA 簇调节多种生物学功能，包括 EMT。本综述讨论了 miRNA 簇在 EMT 中的作用。
