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miR-30家族成员通过抑制XB130的表达水平来抑制非小细胞肺癌细胞的上皮-间质转化。

Members of the miR-30 family inhibit the epithelial-to-mesenchymal transition of non-small-cell lung cancer cells by suppressing XB130 expression levels.

作者信息

Song Kewei, Jiang Yinhui, Zhao Yan, Xie Yuan, Zhou Jianjiang, Yu Wenfeng, Wang Qinrong

机构信息

College of Sport and Health and Key Laboratory of Endemic and Ethnic Diseases of The Ministry of Education, Guizhou Medical University, Guiyang, Guizhou 550004, P.R. China.

Key Laboratory of Medical Molecular Biology, Guizhou Medical University, Guiyang, Guizhou 550004, P.R. China.

出版信息

Oncol Lett. 2020 Oct;20(4):68. doi: 10.3892/ol.2020.11929. Epub 2020 Jul 29.

DOI:10.3892/ol.2020.11929
PMID:32863901
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7436119/
Abstract

MicroRNAs (miRs) are associated with cancer metastasis. Aberrant expression levels of members of the miR-30 family have been observed in non-small-cell lung cancer (NSCLC). However, the effects of miR-30 family members on the epithelial-to-mesenchymal transition (EMT) of NSCLC cells and the underlying molecular mechanisms have not yet been fully elucidated. The present study investigated the effects of miR-30 family members on EMT, migration and invasion of NSCLC cells and found that overexpression of these miRs inhibited EMT via decreasing the expression levels of N-cadherin, β-catenin and SNAI1, along with weakened migration and invasion abilities. Then, XB130 was identified as a downstream target of the miR-30 family members. XB130-knockdown also inhibited EMT of NSCLC cells, whereas ectopic overexpression of XB130 partly rescued the suppressive effects of miR-30c and miR-30d on EMT. In conclusion, miR-30 family members inhibited EMT of NSCLC cells, partially via suppressing XB130 expression levels.

摘要

微小RNA（miR）与癌症转移相关。在非小细胞肺癌（NSCLC）中已观察到miR-30家族成员的异常表达水平。然而，miR-30家族成员对NSCLC细胞上皮-间质转化（EMT）的影响及其潜在分子机制尚未完全阐明。本研究调查了miR-30家族成员对NSCLC细胞EMT、迁移和侵袭的影响，发现这些miR的过表达通过降低N-钙黏蛋白、β-连环蛋白和SNAI1的表达水平来抑制EMT，同时迁移和侵袭能力减弱。然后，XB130被鉴定为miR-30家族成员的下游靶点。敲低XB130也抑制了NSCLC细胞的EMT，而XB130的异位过表达部分挽救了miR-30c和miR-30d对EMT的抑制作用。总之，miR-30家族成员抑制NSCLC细胞的EMT，部分是通过抑制XB130的表达水平来实现的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2486/7436119/3fe359c666ae/ol-20-04-11929-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2486/7436119/b7e866f9f031/ol-20-04-11929-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2486/7436119/2672a9e57e73/ol-20-04-11929-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2486/7436119/79bb3f0358eb/ol-20-04-11929-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2486/7436119/3fe359c666ae/ol-20-04-11929-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2486/7436119/b7e866f9f031/ol-20-04-11929-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2486/7436119/2672a9e57e73/ol-20-04-11929-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2486/7436119/79bb3f0358eb/ol-20-04-11929-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2486/7436119/3fe359c666ae/ol-20-04-11929-g03.jpg

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