急性移植物抗宿主病（GVHD）后产生的梭菌与类固醇难治性 GVHD 的发生有关。
Butyrogenic bacteria after acute graft-versus-host disease (GVHD) are associated with the development of steroid-refractory GVHD.
机构信息
Division of Infectious Diseases, Department of Medicine, University of Michigan, Ann Arbor, MI.
Infectious Disease Sciences, Vaccines and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA.
出版信息
Blood Adv. 2019 Oct 8;3(19):2866-2869. doi: 10.1182/bloodadvances.2019000362.
Abstract
The presence of butyrogenic bacteria after the onset of acute GVHD associates with subsequent steroid-refractory GVHD or chronic GVHD. Butyrate inhibits human colonic stem cells from forming an intact epithelial monolayer.
摘要
急性移植物抗宿主病发病后存在丁酸产生菌与随后的类固醇难治性移植物抗宿主病或慢性移植物抗宿主病相关。丁酸可抑制人结肠干细胞形成完整的上皮单层。
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