Infectious and Tropical Diseases Research Center, Health Research Institute, Parasitology Department, Medical School, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Parasitology Department, Medical School, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Acta Trop. 2020 Jan;201:105206. doi: 10.1016/j.actatropica.2019.105206. Epub 2019 Oct 2.
Albendazole is appropriate chemotherapy for treatment and prophylaxis of cystic echinococcosis (CE). The recent studies show Cytokine therapy could be useful for chronic and progressive diseases, therefore, the use of cytokine in prophylaxis and treatment of hydatidosis could be considerable. The aim of this study is to evaluate the efficacy of interleukin-12 + interferon-gamma, in combination with albendazole for prophylaxis and treatment of CE in Balb/c mice. Albendazole and cytokines were administrated for prophylaxis and treatment in CE. The efficacy of this agents were determined by measuring of size, weight, number of cysts, histology and lymphocyte response. Lymphocyte stimulation index and production of interleukin-12 and interferon-gamma were measured by MTT assay and ELISA respectively. Combination of albendazole and cytokines was very effective for prophylaxis and treatment in experimental CE.
阿苯达唑是治疗和预防囊型包虫病（CE）的合适化疗药物。最近的研究表明，细胞因子治疗对于慢性和进行性疾病可能是有用的，因此，细胞因子在包虫病的预防和治疗中的应用可能是相当可观的。本研究旨在评估白细胞介素-12（IL-12）+干扰素-γ联合阿苯达唑在预防和治疗 Balb/c 小鼠 CE 中的疗效。阿苯达唑和细胞因子用于 CE 的预防和治疗。通过测量大小、重量、囊肿数量、组织学和淋巴细胞反应来确定这些药物的疗效。淋巴细胞刺激指数和白细胞介素-12 和干扰素-γ的产生分别通过 MTT 测定和 ELISA 测定。阿苯达唑和细胞因子联合应用对实验性 CE 的预防和治疗非常有效。
