接受羟钴胺治疗有效的巨幼细胞贫血患者的淋巴细胞亚群
Lymphocyte subpopulations in patients with hydroxocobalamin responsive megaloblastic anaemia.
作者信息
Wodzinski M A, Forrest M J, Barnett D, Lawrence A C
出版信息
J Clin Pathol. 1985 May;38(5):582-4. doi: 10.1136/jcp.38.5.582.
Abstract
Lymphocyte subpopulations and intrinsic factor and gastric parietal cell antibodies have been measured in 23 patients with megaloblastic anaemia who responded to treatment with hydroxocobalamin. The ratio of helper (OKT4) to suppressor (OKT8) lymphocytes was significantly increased in patients with intrinsic factor antibody compared with those who lacked the antibody. No such correlation was found for gastric parietal cell antibody. Alterations in the lymphocyte helper to suppressor (OKT4:OKT8) ratio may be associated with pernicious anaemia.
摘要
对23例经羟钴胺治疗有效的巨幼细胞贫血患者进行了淋巴细胞亚群、内因子及胃壁细胞抗体检测。与缺乏内因子抗体的患者相比，存在内因子抗体的患者中辅助性（OKT4）淋巴细胞与抑制性（OKT8）淋巴细胞的比例显著升高。未发现胃壁细胞抗体与该比例有此类相关性。淋巴细胞辅助/抑制（OKT4:OKT8）比例的改变可能与恶性贫血有关。
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本文引用的文献
1
Lymphocyte subpopulations in pernicious anemia.
N Engl J Med. 1984 Jul 5;311(1):56. doi: 10.1056/nejm198407053110117.
2
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Clin Exp Immunol. 1981 Sep;45(3):475-9.
3
The use of monoclonal anti-T cell antibodies to study T cell imbalances in human diseases.使用单克隆抗T细胞抗体研究人类疾病中的T细胞失衡。
Clin Exp Immunol. 1981 Sep;45(3):449-56.
4
Current concepts in immunology: Regulation of the immune response--inducer and suppressor T-lymphocyte subsets in human beings.免疫学的当前概念：免疫应答的调节——人类中的诱导性和抑制性T淋巴细胞亚群。
N Engl J Med. 1980 Aug 14;303(7):370-3. doi: 10.1056/NEJM198008143030704.
5
Gastric mucosal lymphocyte subpopulations in pernicious anemia and in normal stomach.恶性贫血和正常胃中的胃黏膜淋巴细胞亚群
Clin Immunol Immunopathol. 1983 Sep;28(3):431-40. doi: 10.1016/0090-1229(83)90110-1.
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