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1
The use of monoclonal anti-T cell antibodies to study T cell imbalances in human diseases.使用单克隆抗T细胞抗体研究人类疾病中的T细胞失衡。
Clin Exp Immunol. 1981 Sep;45(3):449-56.
2
Enumeration of T lymphocytes subsets in autoimmune disease using monoclonal antibodies.使用单克隆抗体对自身免疫性疾病中的T淋巴细胞亚群进行计数。
Clin Exp Immunol. 1981 Sep;45(3):475-9.
3
The significance of T-cell subsets defined by monoclonal antibodies in human diseases.单克隆抗体所定义的T细胞亚群在人类疾病中的意义。
Ann Immunol (Paris). 1982 Sep-Oct;133D(2):131-6.
4
Clinical disorders associated with T cell subset abnormalities.与T细胞亚群异常相关的临床疾病。
Adv Pediatr. 1984;31:447-80.
5
Evaluation of T cell subsets in myasthenia gravis using anti-T cell monoclonal antibodies.使用抗T细胞单克隆抗体评估重症肌无力患者的T细胞亚群。
Clin Exp Immunol. 1981 Jul;45(1):1-8.
6
Delineation of human thymocyte differentiation pathways utilizing double-staining techniques with monoclonal antibodies.利用单克隆抗体双染色技术描绘人类胸腺细胞分化途径。
Clin Exp Immunol. 1981 Sep;45(3):457-67.
7
Abnormal T lymphocyte subpopulations in patients with B cell chronic lymphocytic leukemia: an analysis by monoclonal antibodies.B 细胞慢性淋巴细胞白血病患者的异常 T 淋巴细胞亚群：单克隆抗体分析
J Immunol. 1982 Nov;129(5):2305-12.
8
Diagnostic and therapeutic applications of monoclonal antibodies to human T-cell subsets in renal transplant recipients.单克隆抗体在肾移植受者人T细胞亚群中的诊断和治疗应用
Urol Clin North Am. 1983 May;10(2):289-99.
9
Lymphocytotoxic antibodies.淋巴细胞毒性抗体
Prog Clin Immunol. 1980;4:151-54.
10
Antithymocyte antisera globulin effect on human lymphoid neoplasia.
Arch Intern Med. 1973 Aug;132(2):171-4.

引用本文的文献

1
Emerging opportunities for site-specific molecular and cellular interventions in autoimmune hepatitis.自身免疫性肝炎中特异性分子和细胞干预的新机遇。
Dig Dis Sci. 2010 Oct;55(10):2712-26. doi: 10.1007/s10620-009-1122-8. Epub 2010 Jan 27.
2
Autoimmune diseases: immunopathology and etiopathogenesis.自身免疫性疾病：免疫病理学与病因发病机制
Am J Pathol. 1982 Sep;108(3):319-65.
3
Monoclonal antibody-defined immunoregulatory cells in multiple sclerosis cerebrospinal fluid.多发性硬化症脑脊液中由单克隆抗体定义的免疫调节细胞。
J Clin Invest. 1982 Aug;70(2):387-92. doi: 10.1172/jci110628.
4
Imbalance of T cell subpopulations in patients with chronic lymphocytic leukaemia of the B cell type.B 细胞型慢性淋巴细胞白血病患者 T 细胞亚群失衡。
Clin Exp Immunol. 1982 Jul;49(1):157-62.
5
Enumeration of lymphocyte populations defined by surface markers in the whole blood of patients with Crohn's disease.对克罗恩病患者全血中由表面标志物定义的淋巴细胞群体进行计数。
Gut. 1982 Sep;23(9):766-9. doi: 10.1136/gut.23.9.766.
6
Lymphocyte subsets in the peripheral blood of patients with multiple myeloma and benign monoclonal gammopathy.多发性骨髓瘤和良性单克隆丙种球蛋白病患者外周血中的淋巴细胞亚群。
Klin Wochenschr. 1983 Aug 15;61(16):819-21. doi: 10.1007/BF01496728.
7
Lymphocyte subsets in measles. Depressed helper/inducer subpopulation reversed by in vitro treatment with levamisole and ascorbic acid.麻疹中的淋巴细胞亚群。左旋咪唑和抗坏血酸体外治疗可逆转辅助/诱导亚群降低的情况。
J Clin Invest. 1983 Sep;72(3):971-80. doi: 10.1172/JCI111069.
8
T-lymphocyte subpopulations in relation to immunosuppression in measles and varicella.麻疹和水痘中与免疫抑制相关的T淋巴细胞亚群
Infect Immun. 1983 Jan;39(1):29-37. doi: 10.1128/iai.39.1.29-37.1983.
9
The immunological basis of inflammatory diseases.炎症性疾病的免疫学基础。
Inflammation. 1984 Jun;8 Suppl:S43-8. doi: 10.1007/BF00915711.
10
Monoclonal antibodies against differentiation antigens of lymphopoiesis.抗淋巴细胞分化抗原的单克隆抗体。
Blut. 1983 Nov;47(5):247-61. doi: 10.1007/BF00319894.

本文引用的文献

1
Delineation of a human T cell subset responsible for lepromin-induced suppression in leprosy patients.确定麻风病患者中负责麻风菌素诱导抑制作用的人类T细胞亚群。
J Immunol. 1980 Sep;125(3):1183-8.
2
Simple and rapid measurement of human T lymphocytes and their subclasses in peripheral blood.外周血中人类T淋巴细胞及其亚群的简单快速检测
Proc Natl Acad Sci U S A. 1980 Aug;77(8):4914-7. doi: 10.1073/pnas.77.8.4914.
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Monoclonal antibodies which distinguish between human NK cells and cytotoxic T lymphocytes.可区分人自然杀伤细胞和细胞毒性T淋巴细胞的单克隆抗体。
Nature. 1980 Nov 27;288(5789):394-6. doi: 10.1038/288394a0.
4
Human T lymphocytes of inducer and suppressor type occupy different microenvironments.诱导型和抑制型人类T淋巴细胞占据不同的微环境。
Nature. 1980 Nov 6;288(5786):81-4. doi: 10.1038/288081a0.
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Discrete stages of human intrathymic differentiation: analysis of normal thymocytes and leukemic lymphoblasts of T-cell lineage.人类胸腺内分化的离散阶段：T细胞系正常胸腺细胞和白血病淋巴母细胞的分析
Proc Natl Acad Sci U S A. 1980 Mar;77(3):1588-92. doi: 10.1073/pnas.77.3.1588.
6
T cell requirements for generation of helper factor(s) in man: analysis of the subsets involved.人类中产生辅助因子的T细胞需求：对相关亚群的分析。
J Immunol. 1980 Apr;124(4):1883-7.
7
Studies on T cell subsets and functions in leprosy.麻风病中T细胞亚群及功能的研究。
Clin Exp Immunol. 1981 Jun;44(3):491-500.
8
Evaluation of T cell subsets in myasthenia gravis using anti-T cell monoclonal antibodies.使用抗T细胞单克隆抗体评估重症肌无力患者的T细胞亚群。
Clin Exp Immunol. 1981 Jul;45(1):1-8.
9
A monoclonal antibody reactive with the human cytotoxic/suppressor T cell subset previously defined by a heteroantiserum termed TH2.一种单克隆抗体，可与人细胞毒性/抑制性T细胞亚群发生反应，该亚群先前由一种名为TH2的异种抗血清所定义。
J Immunol. 1980 Mar;124(3):1301-7.
10
The cellular basis for viral-induced immunodeficiency: analysis by monoclonal antibodies.病毒诱导免疫缺陷的细胞基础：单克隆抗体分析
J Immunol. 1980 Sep;125(3):1269-74.

使用单克隆抗T细胞抗体研究人类疾病中的T细胞失衡。

The use of monoclonal anti-T cell antibodies to study T cell imbalances in human diseases.

作者信息

Bach M A, Bach J F

出版信息

Clin Exp Immunol. 1981 Sep;45(3):449-56.

PMID:6461443
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1537411/
Abstract

Monoclonal antibodies are now available to evaluate human T cell subsets by direct counting using indirect immunofluorescence analysis. The critical use of these antibodies has already permitted the delineation of the T cell imbalances present in a number of immunologically mediated diseases such as autoimmune haemolytic anaemia, chronic active hepatitis, myasthenia gravis, glomerulonephritides, multiple sclerosis, leprosy, or immunodeficiency syndromes. The potential diagnostic and therapeutic application of this new methodology are emphasized.

摘要

现在可以通过间接免疫荧光分析直接计数来评估人类T细胞亚群的单克隆抗体。这些抗体的关键应用已经能够描绘出许多免疫介导疾病中存在的T细胞失衡情况，如自身免疫性溶血性贫血、慢性活动性肝炎、重症肌无力、肾小球肾炎、多发性硬化症、麻风病或免疫缺陷综合征。强调了这种新方法在诊断和治疗方面的潜在应用。