Department of Public Health, School of Medicine, Jiaxing University, 118 Jiahang Road, Jiaxing, 314-001, China; Faculty of Health Sciences, Institute of Medical Pharmaceutical and Health Sciences, Kanazawa University, 5-11-80 Kodatsuno, Kanazawa, 920-0942, Japan; JSPS International Research Fellow (Centre for Health and Environmental Risk Research, National Institute for Environmental Studies, Japan.
Faculty of Health Sciences, Institute of Medical Pharmaceutical and Health Sciences, Kanazawa University, 5-11-80 Kodatsuno, Kanazawa, 920-0942, Japan.
Chemosphere. 2020 Feb;241:124899. doi: 10.1016/j.chemosphere.2019.124899. Epub 2019 Sep 22.
Recent studies have found elevated dioxin levels inside some former US military air bases in Vietnam, known as hotspots. The aim of the present study was to evaluate the association of dioxin exposure and steroid hormone in preschool children in Vietnam. In 2010, 2011, 52 primiparae mother-infant pairs in the hotspot and 52 pairs in a non-exposure region were enrolled. For the final analysis, 26 vs 26 pairs were selected, who participated at all three surveys. Univariable and multivariable linear regressions were used to evaluate associations between hormone and dioxin congeners. Geometric mean total TEQ of PCDD/DFs in the hotspot were significantly higher than in the non-exposure region, 8.7 and 3.4 pg TEQ/g lipid, respectively. In the hotspot, salivary dehydroepiandrosterone (DHEA) was significantly higher in 1-year-old children (Boys = 123 pg/mL, Girls = 120 pg/mL) than in the non-exposure region (Boys = 28 pg/mL, Girls = 27 pg/mL). In contrast, DHEA was significantly lower in 5-year-old children (Boys = 70 pg/mL, Girls = 106 pg/mL) in the hotspot than in the non-exposure region (Boys = 496 pg/mL, Girls = 654 pg/mL). Salivary testosterone was significantly lower in the hotspot (Boys = 1.9 pg/mL, Girls = 1.9 pg/m; Boys = 1.0 pg/mL, Girls = 1.1 pg/mL, respectively) than in the non-exposure region (Boys = 3.7 pg/mL, Girls = 3.8 pg/m; Boys = 5.7 pg/mL, Girls = 7.0 pg/mL, respectively) at 3 years and 5 years of age. Higher levels of highly chlorinated dioxins in breast milk were associated with higher DHEA in 1-year-old and lower DHEA and testosterone levels in 5-year-old children. Our findings indicated that dioxins were associated with changes of DHEA and testosterone levels in preschool Vietnamese children.
最近的研究发现，越南一些前美军空军基地（被称为热点地区）内的二恶英水平升高。本研究的目的是评估越南学龄前儿童中二恶英暴露与类固醇激素之间的关系。2010 年和 2011 年，在热点地区和非暴露地区分别招募了 52 对初产妇母婴对和 52 对母婴对。最终分析时，选择了所有三个调查都参加的 26 对母婴对和 26 对母婴对进行分析。使用单变量和多变量线性回归来评估激素与二恶英同系物之间的关系。热点地区 PCDD/DF 总量 TEQ 的几何均值明显高于非暴露地区，分别为 8.7 和 3.4 pg TEQ/g 脂质。在热点地区，1 岁儿童唾液脱氢表雄酮（DHEA）明显高于非暴露地区（男孩为 123 pg/mL，女孩为 120 pg/mL）（男孩为 28 pg/mL，女孩为 27 pg/mL）。相反，5 岁儿童唾液 DHEA 在热点地区明显低于非暴露地区（男孩为 70 pg/mL，女孩为 106 pg/mL）（男孩为 496 pg/mL，女孩为 654 pg/mL）。热点地区唾液睾酮水平明显低于非暴露地区（男孩为 1.9 pg/mL，女孩为 1.9 pg/m；男孩为 1.0 pg/mL，女孩为 1.1 pg/mL）（男孩为 3.7 pg/mL，女孩为 3.8 pg/m；男孩为 5.7 pg/mL，女孩为 7.0 pg/mL），分别在 3 岁和 5 岁时。母乳中二恶英水平较高与 1 岁儿童 DHEA 水平升高以及 5 岁儿童 DHEA 和睾酮水平降低有关。我们的研究结果表明，二恶英与越南学龄前儿童 DHEA 和睾酮水平的变化有关。
